CAJ | 학술논문

目的：探讨双联抗血小板药物对急性脑梗死患者血清S100β蛋白、白细胞介素1β（ IL－1β）、脂联素（ ADPN）及神经功能评分（ NIHSS）的影响。方法收集河北省秦皇岛市第一医院收治的急性脑梗死患者58例，按照随机数字表分为对照组和实验组，每组各29例，均给予改善脑血管循环、保护脑细胞、控制血压、血糖、必要时吸氧等常规治疗。对照组在常规治疗基础上给予阿司匹林200 mg，1次／天，口服治疗；实验组在对照组治疗基础上加用氯吡格雷75 mg，1次／天，口服治疗，均治疗2周。治疗结束后，对所有患者的血清S100β蛋白、IL－1β、ADPN水平及NIHSS评分进行检测。结果与对照组比较，治疗后实验组患者的血清S－100β蛋白水平显著降低（P＜0．05），血清IL－1β水平显著降低（P＜0．05），血清ADPN水平显著升高（P＜0．05），NIHSS评分显著降低（P＜0．05）。结论双联抗血小板药物能够降低急性脑梗死患者血清中S－100β蛋白和IL－1β水平，提高ADPN水平，降低NIHSS评分，能够有效改善患者的神经功能。
목적：탐토쌍련항혈소판약물대급성뇌경사환자혈청S100β단백、백세포개소1β（ IL－1β）、지련소（ ADPN）급신경공능평분（ NIHSS）적영향。방법수집하북성진황도시제일의원수치적급성뇌경사환자58례，안조수궤수자표분위대조조화실험조，매조각29례，균급여개선뇌혈관순배、보호뇌세포、공제혈압、혈당、필요시흡양등상규치료。대조조재상규치료기출상급여아사필림200 mg，1차／천，구복치료；실험조재대조조치료기출상가용록필격뢰75 mg，1차／천，구복치료，균치료2주。치료결속후，대소유환자적혈청S100β단백、IL－1β、ADPN수평급NIHSS평분진행검측。결과여대조조비교，치료후실험조환자적혈청S－100β단백수평현저강저（P＜0．05），혈청IL－1β수평현저강저（P＜0．05），혈청ADPN수평현저승고（P＜0．05），NIHSS평분현저강저（P＜0．05）。결론쌍련항혈소판약물능구강저급성뇌경사환자혈청중S－100β단백화IL－1β수평，제고ADPN수평，강저NIHSS평분，능구유효개선환자적신경공능。
Objective To analyse the effect of dual-antiplatelet drugs on S100β,IL-1β, adiponectin(ADPN)and NIHSS score in patients with acute cerebral infarction.Methods 58 patients diagnosed with acute cerebral infarction in first hospital of Qinhuangdao.All patients were collected and randomly divided into experimental group and control group according to random number table , 29 cases in each group.Both group were given the treatrnent of improvng the cerebral vascular circulation, protect brain cells, control blood pressure, blood glucose, oxygen when necessary.On the basis of conventional treatment, control group was treated with aspirin 200 mg, one time per day,orally.And experimental group was treated with clopidogrel 75 mg/d on the basis of control group,one time per day,orally.After treatment, the serum levels of S100β, IL-1β, ADPN and NIHSS score were detected in all patients.ResuIts After treatment, compared with control group,the serum S100βprotein level was significantly lower in the experimental group (P<0.05); the serum IL-1βlevel in experimental group was significantly lower (P<0.05);ADPN level in experimental group was significantly higher (P<0.05); NIHSS score of patients in experimental group was significantly lower (P<0.05).ConcIusions Dual antiplatelet drugs can reduce serum S100βprotein,IL-1βin serum of patients with acute cerebral infarction, increase the level of serum adiponectin, decrease NIHSS score, can effectively improre neurological function in patients with acute cerebral infarction.