CAJ | 학술논문

目的：探讨银杏叶提取物对帕金森患者血清黑质二价金属离子转运蛋白（divalent metal transporter1，DMT1）、葡萄糖调节蛋白75（ glucose regulated protein 75，grp75）及神经功能的影响。方法帕金森患者38例，根据用药不同分为对照组和实验组，每组各19例，对照组患者给予多巴丝肼片，实验组在对照组的基础上给予银杏叶提取物片，治疗连续4周。治疗结束后，对所有患者黑质DMT1、grp75及认知功能进行检测。结果与治疗前相比，治疗后2组患者的黑质DMT1水平较低（ P＜0．05）；与对照组相比，实验组患者治疗后黑质DMT1水平较低（P＜0．05）。与治疗前相比，治疗后2组患者的grp75水平较高（P＜0．05），与对照组相比，实验组患者治疗后grp75水平较高（P＜0．05）。与治疗前相比，治疗后2组患者的MoCA评分较高（P＜0．05），HAMD评分较低（P＜0．05）；与对照组相比，实验组患者治疗后MoCA评分较高（P＜0．05），HAMD评分较低（P＜0．05）。结论银杏叶提取物能够显著降低帕金森患者黑质DMT1水平，升高grp75水平，改善认知功能。
목적：탐토은행협제취물대파금삼환자혈청흑질이개금속리자전운단백（divalent metal transporter1，DMT1）、포도당조절단백75（ glucose regulated protein 75，grp75）급신경공능적영향。방법파금삼환자38례，근거용약불동분위대조조화실험조，매조각19례，대조조환자급여다파사정편，실험조재대조조적기출상급여은행협제취물편，치료련속4주。치료결속후，대소유환자흑질DMT1、grp75급인지공능진행검측。결과여치료전상비，치료후2조환자적흑질DMT1수평교저（ P＜0．05）；여대조조상비，실험조환자치료후흑질DMT1수평교저（P＜0．05）。여치료전상비，치료후2조환자적grp75수평교고（P＜0．05），여대조조상비，실험조환자치료후grp75수평교고（P＜0．05）。여치료전상비，치료후2조환자적MoCA평분교고（P＜0．05），HAMD평분교저（P＜0．05）；여대조조상비，실험조환자치료후MoCA평분교고（P＜0．05），HAMD평분교저（P＜0．05）。결론은행협제취물능구현저강저파금삼환자흑질DMT1수평，승고grp75수평，개선인지공능。
Objective To investigate the effect of Ginkgo biloba extract on serum divalent metal transporter1 ( DMT1 ) , glucose regulated protein 75(grp75) and nerve function in patients with Parkinson disease.Methods 38 cases of patients loith parkinson disease according to different drugs were divided into experimental group and control group, 19 cases in each group.Control group was treated with levodopa and Benserazide tablet, experimental group on the basis of control group, was given Ginkgo biloba extract tablets, treatment for 4 weeks.After treatment, DMT1, grp75 and cognitive function of all patients in substantia nigra were detected.ResuIts Compared with before treatment, two groups of patients with lower DMT1 level (P<0.05), compared with control group, experimental group of patients with lower DMT1 levels (P<0.05).Compared with pre-treatment, two groups of patients grp75 level was higher (P<0.05), compared with control group, experimental group after treatment grp75 level was higher (P<0.05).Compared with before treatment, the two groups of patients with MoCA scores were higher (P<0.05), HAMD scores were lower (P<0.05).Compared with control group, experimental group after treatment MoCA scores were higher (P<0.05), HAMD scores were lower (P<0.05).ConcIusion Ginkgo biloba extract can significantly reduce the level of DMT1 in the substantia nigra of Parkinson patients, increase the level of grp75, and improve the cognitive function.