中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2015年
16期
82-84,115
,共4页
宫颈炎%阴道局部%免疫状态%相关性
宮頸炎%陰道跼部%免疫狀態%相關性
궁경염%음도국부%면역상태%상관성
Cervicitis%Part of vagina%Immune status%Relevance
目的：探讨分析宫颈炎症患者阴道局部免疫状态与疾病发生的相关性。方法选取我院2013年4月～2014年4月收治的250例宫颈炎症患者，分为淋病奈瑟菌宫颈炎（NG，50例）、人型支原体宫颈炎（MH，50例）、宫颈糜烂患者（EC，50例）、沙眼衣原体宫颈炎（CT，50例）、解脲支原体宫颈炎（UU，50例）和250例正常妇女作为对照组，对所有患者进行阴道灌洗，并应用酶联免疫吸附试验检测洗液中肿瘤坏死因子-α（TNF-α)和白细胞介素-8（IL-8）的水平，其中给予观察组宫颈炎康栓配合射频治疗该病，对照组采用常规射频治疗，对比其疗效和局部免疫状态与疾病发生的相关性。结果阴道灌洗液TNF-α水平，除宫颈糜烂患者（EC）组之外，其余各组均高于对照组，组间比较差异有统计学意义（P＜0.01）。阴道灌洗液IL-8水平，NG组为（336±35）ng/L，MH组为（369±33）ng/L，CT组为（363±31）ng/L，三组和对照组相比，为（314±33）ng/L，（343±35）ng/L及（337±36）ng/L，组间比较差异有统计学意义（P＜0.05）。UU组和EC组与对照组比较差异无统计学意义（P＞0.05）。宫颈炎组治疗总有效率优于对照组（P＜0.05）。结论阴道局部免疫状态在各种宫颈炎症的发病机制中发挥了重要作用，尤其在与疾病发生的相关性中IL-8在人型支原体宫颈炎、沙眼衣原体宫颈炎及淋病奈瑟菌宫颈炎中有更重要的作用。
目的：探討分析宮頸炎癥患者陰道跼部免疫狀態與疾病髮生的相關性。方法選取我院2013年4月～2014年4月收治的250例宮頸炎癥患者，分為淋病奈瑟菌宮頸炎（NG，50例）、人型支原體宮頸炎（MH，50例）、宮頸糜爛患者（EC，50例）、沙眼衣原體宮頸炎（CT，50例）、解脲支原體宮頸炎（UU，50例）和250例正常婦女作為對照組，對所有患者進行陰道灌洗，併應用酶聯免疫吸附試驗檢測洗液中腫瘤壞死因子-α（TNF-α)和白細胞介素-8（IL-8）的水平，其中給予觀察組宮頸炎康栓配閤射頻治療該病，對照組採用常規射頻治療，對比其療效和跼部免疫狀態與疾病髮生的相關性。結果陰道灌洗液TNF-α水平，除宮頸糜爛患者（EC）組之外，其餘各組均高于對照組，組間比較差異有統計學意義（P＜0.01）。陰道灌洗液IL-8水平，NG組為（336±35）ng/L，MH組為（369±33）ng/L，CT組為（363±31）ng/L，三組和對照組相比，為（314±33）ng/L，（343±35）ng/L及（337±36）ng/L，組間比較差異有統計學意義（P＜0.05）。UU組和EC組與對照組比較差異無統計學意義（P＞0.05）。宮頸炎組治療總有效率優于對照組（P＜0.05）。結論陰道跼部免疫狀態在各種宮頸炎癥的髮病機製中髮揮瞭重要作用，尤其在與疾病髮生的相關性中IL-8在人型支原體宮頸炎、沙眼衣原體宮頸炎及淋病奈瑟菌宮頸炎中有更重要的作用。
목적：탐토분석궁경염증환자음도국부면역상태여질병발생적상관성。방법선취아원2013년4월～2014년4월수치적250례궁경염증환자，분위임병내슬균궁경염（NG，50례）、인형지원체궁경염（MH，50례）、궁경미란환자（EC，50례）、사안의원체궁경염（CT，50례）、해뇨지원체궁경염（UU，50례）화250례정상부녀작위대조조，대소유환자진행음도관세，병응용매련면역흡부시험검측세액중종류배사인자-α（TNF-α)화백세포개소-8（IL-8）적수평，기중급여관찰조궁경염강전배합사빈치료해병，대조조채용상규사빈치료，대비기료효화국부면역상태여질병발생적상관성。결과음도관세액TNF-α수평，제궁경미란환자（EC）조지외，기여각조균고우대조조，조간비교차이유통계학의의（P＜0.01）。음도관세액IL-8수평，NG조위（336±35）ng/L，MH조위（369±33）ng/L，CT조위（363±31）ng/L，삼조화대조조상비，위（314±33）ng/L，（343±35）ng/L급（337±36）ng/L，조간비교차이유통계학의의（P＜0.05）。UU조화EC조여대조조비교차이무통계학의의（P＞0.05）。궁경염조치료총유효솔우우대조조（P＜0.05）。결론음도국부면역상태재각충궁경염증적발병궤제중발휘료중요작용，우기재여질병발생적상관성중IL-8재인형지원체궁경염、사안의원체궁경염급임병내슬균궁경염중유경중요적작용。
ObjectiveTo explore and analyze the relevance between part of vagina's immune status and occurrence of disease of patients with cervicitis.Methods250 patients with cervicitis who were admitted to our hospital from April 2013 to April 2014 were allocated into Neisseria gonorrhoeae cervicitis group (NG, 50 patients), Mycoplasma hominis cervicitis group (MH, 50 cases), erosion of cervix group (EC, 50 cases), cervicitis of chlamydia trachomatis group (CT, 50 cases) and urea solution mycoplasma cervicitis group (UU, 50 cases), and 250 healthy women were selected as control group. All patients were received vaginal douche, and enzyme-linked immunosorbent assay was used to detect tumor necrosis factor -α(TNF-α) level and interleukin -8 (IL-8) level in vaginal douche fluid. The observation group was treated with cervicitis suppository combined with radiofrequency ablation, and the control group was treated with conventional radiofrequency ablation. The curative effect and the relevance between part of vagina's immune statues and occurrence of diseases of two groups were compared.Results TNF α levels of all groups except EC group were higher than that of control group, and the comparison among groups was statistically significant (P<0.01). IL-8 levels in vaginal douche fluid of NG group, MH group and CT group were (336±35)ng/L, (369±33)ng/L and (363±31)ng/L respectively, which were compared with those of control group (314±33)ng/L, (343±35)ng/L and (337±36) ng/L. The difference were statistically significant (P<0.05). The comparison between UU group and EC group and control group was not statistically significant (P>0.05). The total effective rate of treatment of cervicitis was better than that of control group (P<0.05).Conclusion The immune status of parts of vagina plays an important role of the pathogenesis of all kinds of cervicitis, especially in relevance with disease occurring in IL-8 in Mycoplasma hominis.
