CAJ | 학술논문

目的：观察并探讨Onyx胶栓塞治疗对脑动静脉畸形（CAVM）的有效性和安全性。方法选择自2010年6月~2014年1月在本院住院治疗的CAVM患者96例，按照随机分组法将96例患者分为两组，观察组和对照组各48例，观察组给予Onyx胶栓塞治疗，而对照组给予NBCA胶栓塞治疗。治疗后统计两组患者的栓塞率≥80%比率、复发率、平均体积缩小、术后恢复时间和住院时间及并发症发生情况。结果观察组栓塞率≥80%比率、复发率分别为87.5%（42/48）和0，对照组为66.7%（32/48）和12.5%（6/48），两组相比，差异有统计学意义（P＜0.05）；观察组平均体积缩小、术后恢复时间和住院时间分别为（12.5±2.9）cm3、（25.4±4.9）h和（15.8±1.9）d，对照组为（9.6±2.4）cm3、（25.9±4.6）h和（16.2±1.8）d，两组平均体积缩小相比，差异具有统计学意义（P＜0.05）；观察组并发症率为4.2%（2/48），对照组为10.4%（5/48），两组相比，差异无统计学意义（P＞0.05）。结论 Onyx胶栓塞治疗能明显改善CAVM患者的临床症状，疗效显著，是安全有效的疗法。
목적：관찰병탐토Onyx효전새치료대뇌동정맥기형（CAVM）적유효성화안전성。방법선택자2010년6월~2014년1월재본원주원치료적CAVM환자96례，안조수궤분조법장96례환자분위량조，관찰조화대조조각48례，관찰조급여Onyx효전새치료，이대조조급여NBCA효전새치료。치료후통계량조환자적전새솔≥80%비솔、복발솔、평균체적축소、술후회복시간화주원시간급병발증발생정황。결과관찰조전새솔≥80%비솔、복발솔분별위87.5%（42/48）화0，대조조위66.7%（32/48）화12.5%（6/48），량조상비，차이유통계학의의（P＜0.05）；관찰조평균체적축소、술후회복시간화주원시간분별위（12.5±2.9）cm3、（25.4±4.9）h화（15.8±1.9）d，대조조위（9.6±2.4）cm3、（25.9±4.6）h화（16.2±1.8）d，량조평균체적축소상비，차이구유통계학의의（P＜0.05）；관찰조병발증솔위4.2%（2/48），대조조위10.4%（5/48），량조상비，차이무통계학의의（P＞0.05）。결론 Onyx효전새치료능명현개선CAVM환자적림상증상，료효현저，시안전유효적요법。
Objective To observe and explore the clinical value and safety of Onyx glue embolization in patients with cerebral arteriovenous malformation(CAVM). Methods 96 patients with CAVM in this hospital from June 2010 to January 2014 were selected, all the patients were randomized divided into two groups, 48 cases in the observation group and 48 cases in the control group, the observation group were treated with Onyx glue embolization, while the control group were treated with NBCA glue embolization. Occlusion rate ≥80%, recurrence rate, the average reduced volume, postoperative recovery time and hospital stay, as well as complications were observed in the two groups after treatment.ResultsThe ratio of occlusion rate≥80% and recurrence in observation group was 87.5%(42/48) and 0, while was 66.7%(32/48) and 12.5%(6/48) in the control group, the difference was statistically significance(P<0.05); the average reduced volume, postoperative recovery time and hospitalization time were (12.5±2.9)cm3,(25.4±4.9) h and (15.8±1.9)d in observation group, while was(9.6±2.4)cm3, (25.9±4.6)h and (16.2±1.8)d in the control group, the difference the average reduced volume between the two groups was statistically significant (P<0.05); complication rate was 4.2%(2/48) in the observation group, and was 10.4%(5/48) in the control group, the difference was not statistically significant(P>0.05).Conclusion Onyx glue embolization can significantly improve the clinical symptoms of CAVM patients, with significant effect, thus is safe and effective therapy.