中国免疫学杂志
中國免疫學雜誌
중국면역학잡지
CHINESE JOURNAL OF IMMUNOLOGY
2015年
9期
1253-1256
,共4页
CD4+CD25+调节性T细胞%Foxp3%妊娠期高血压疾病
CD4+CD25+調節性T細胞%Foxp3%妊娠期高血壓疾病
CD4+CD25+조절성T세포%Foxp3%임신기고혈압질병
CD4+CD25+regulatory T cells%Foxp3%Hypertensive disorder complicating pregnancy
目的：探讨妊娠期高血压疾病患者（ HDCP ）外周血中CD4＋CD25＋Foxp3＋调节性T细胞水平变化及其意义。方法：选取2013年1月至2014年8月在我院治疗的妊娠期高血压疾病（ HDCP）患者46例，其中轻度子痫前期22例，重度子痫前期24例，同时选取同期正常孕妇25例，采用流式细胞术检测各组患者外周血CD4＋CD25＋Foxp3＋调节性T细胞。结果：重度子痫前期组CD4＋CD25＋T细胞比例为（5.01±1.04）％，低于轻度子痫前期组的（7.38±1.26）％和正常孕妇组的（12.59±2.48）％，差异有统计学意义（ P＜0.05）；轻度子痫前期组和重度子痫前期组CD4＋CD25＋Foxp3＋T细胞绝对数分别为（0.96±0.11）×107和（0.63±0.12）×107，CD4＋CD25＋Foxp3＋Treg／CD4＋T分别为（2.58±0.93）％和（1.84±0.85）％，均低于正常孕妇组的（1.85±0.17）×107和（5.11±0.99）％，差异有统计学意义（P＜0.05）；轻度子痫前期组和重度子痫前期组血清雌三醇分别为（6.16±2.17）mg／L和（3.27±1.15）mg／L，明显低于正常孕妇组的（11.34±2.4）mg／L，差异有统计学意义（P＜0.05）。结论：妊娠高血压疾病患者CD4＋CD25＋Foxp3＋调节性T细胞明显减少，同时血清雌三醇也有所降低，这些可能与妊娠期高血压疾病的发病机制以及免疫耐受有关。
目的：探討妊娠期高血壓疾病患者（ HDCP ）外週血中CD4＋CD25＋Foxp3＋調節性T細胞水平變化及其意義。方法：選取2013年1月至2014年8月在我院治療的妊娠期高血壓疾病（ HDCP）患者46例，其中輕度子癇前期22例，重度子癇前期24例，同時選取同期正常孕婦25例，採用流式細胞術檢測各組患者外週血CD4＋CD25＋Foxp3＋調節性T細胞。結果：重度子癇前期組CD4＋CD25＋T細胞比例為（5.01±1.04）％，低于輕度子癇前期組的（7.38±1.26）％和正常孕婦組的（12.59±2.48）％，差異有統計學意義（ P＜0.05）；輕度子癇前期組和重度子癇前期組CD4＋CD25＋Foxp3＋T細胞絕對數分彆為（0.96±0.11）×107和（0.63±0.12）×107，CD4＋CD25＋Foxp3＋Treg／CD4＋T分彆為（2.58±0.93）％和（1.84±0.85）％，均低于正常孕婦組的（1.85±0.17）×107和（5.11±0.99）％，差異有統計學意義（P＜0.05）；輕度子癇前期組和重度子癇前期組血清雌三醇分彆為（6.16±2.17）mg／L和（3.27±1.15）mg／L，明顯低于正常孕婦組的（11.34±2.4）mg／L，差異有統計學意義（P＜0.05）。結論：妊娠高血壓疾病患者CD4＋CD25＋Foxp3＋調節性T細胞明顯減少，同時血清雌三醇也有所降低，這些可能與妊娠期高血壓疾病的髮病機製以及免疫耐受有關。
목적：탐토임신기고혈압질병환자（ HDCP ）외주혈중CD4＋CD25＋Foxp3＋조절성T세포수평변화급기의의。방법：선취2013년1월지2014년8월재아원치료적임신기고혈압질병（ HDCP）환자46례，기중경도자간전기22례，중도자간전기24례，동시선취동기정상잉부25례，채용류식세포술검측각조환자외주혈CD4＋CD25＋Foxp3＋조절성T세포。결과：중도자간전기조CD4＋CD25＋T세포비례위（5.01±1.04）％，저우경도자간전기조적（7.38±1.26）％화정상잉부조적（12.59±2.48）％，차이유통계학의의（ P＜0.05）；경도자간전기조화중도자간전기조CD4＋CD25＋Foxp3＋T세포절대수분별위（0.96±0.11）×107화（0.63±0.12）×107，CD4＋CD25＋Foxp3＋Treg／CD4＋T분별위（2.58±0.93）％화（1.84±0.85）％，균저우정상잉부조적（1.85±0.17）×107화（5.11±0.99）％，차이유통계학의의（P＜0.05）；경도자간전기조화중도자간전기조혈청자삼순분별위（6.16±2.17）mg／L화（3.27±1.15）mg／L，명현저우정상잉부조적（11.34±2.4）mg／L，차이유통계학의의（P＜0.05）。결론：임신고혈압질병환자CD4＋CD25＋Foxp3＋조절성T세포명현감소，동시혈청자삼순야유소강저，저사가능여임신기고혈압질병적발병궤제이급면역내수유관。
Objective:To investigate the changes of the levels of CD 4+CD25+Foxp3+regulatory T cells in HDCP peripheral blood and its significance.Methods: From 2013 January to 2014 August 46 hypertensive disorder complicating pregnancy ( HDCP ) patients treated in our hospital ,including 22 patients with mild preeclampsia ,24 cases of severe preeclampsia ,and 25 normal pregnant women,used flow cytometry detected each group patient peripheral blood CD 4+CD25+Foxp3+regulatory T cells.Results: Severe preeclampsia group CD4+CD25+T cell ratio was (5.01±1.04)%,lower than mild preeclampsia group (7.38±1.26)% and normal pregnant women group ( 12.59 ±2.48 )%, the difference was statistically significant ( P<0.05 );Mild preeclampsia and severe preeclampsia group CD4+CD25+Foxp3+T cell absolute number respectively were (0.96±0.11) ×107 and (0.63±0.12) ×107,CD4+CD25+Foxp3+Treg/CD4+T were (2.58±0.93)%and (1.84±0.85)%,were lower than that of normal pregnant women group (1.85± 0.17) ×107 and(5.11±0.99)%,the difference was statistically significant (P<0.05);Mild preeclampsia group and severe preeclampsia blood estriol were (6.16±2.17) mg/L and (3.27±1.15) mg/L,significantly lower than that of normal pregnant women group (11.34±2.4) mg/L,the difference was statistically significant (P<0.05).Conclusion: Hypertensive disorder complicating pregnancy diseases patient CD 4+CD25+Foxp3+regulatory T cells was significantly reduced ,but also serum estriol reduced ,which may be related to the pathogenesis of gestational hypertension disease and immune tolerance .
