中国免疫学杂志
中國免疫學雜誌
중국면역학잡지
CHINESE JOURNAL OF IMMUNOLOGY
2015年
9期
1239-1241
,共3页
章立%洪庆%金友雨%蔡海波
章立%洪慶%金友雨%蔡海波
장립%홍경%금우우%채해파
组织因子%组织因子途径抑制物%糖尿病脑梗死%病情严重程度
組織因子%組織因子途徑抑製物%糖尿病腦梗死%病情嚴重程度
조직인자%조직인자도경억제물%당뇨병뇌경사%병정엄중정도
Tissue factor%Tissue factor pathway inhibitor%Diabetic cerebral infarction%Severity
目的：探讨组织因子（ TF）、组织因子途径抑制物（ TFPI）在糖尿病脑梗死急性期的变化及与病情严重程度的关系。方法：以糖尿病脑梗死患者为研究对象，以美国国立卫生研究院卒中评分（ NIHSS）评价病情严重程度，以单因素分析、多元线性回归分析和相关分析相结合方法探讨TF、TFPI与糖尿病脑梗死患者病情严重程度的关系。结果：NIHSS评分≤12分组TF、TFPI、TF／TFPI、胆固醇和甘油三酯均显著低于NIHSS评分＞12分组，差异有统计学意义（均P＜0.01）；NIHSS评分与TF（r＝0.354，P＝0.012）、TFPI（r＝0.302，P＝0.027）、TF／TFPI（r＝0.410，P＝0.000）、胆固醇（r＝0.364，P＝0.006）和甘油三酯（ r＝0.334，P＝0.018）显著正相关；多元线性回归分析，结果表明TF、TFPI、TF／TFPI、胆固醇为糖尿病脑梗死患者病情严重程度的独立危险因素（ P＜0.05）。结论：急性期血清TF和TFPI可能与糖尿病脑梗死患者的病情严重程度相关。
目的：探討組織因子（ TF）、組織因子途徑抑製物（ TFPI）在糖尿病腦梗死急性期的變化及與病情嚴重程度的關繫。方法：以糖尿病腦梗死患者為研究對象，以美國國立衛生研究院卒中評分（ NIHSS）評價病情嚴重程度，以單因素分析、多元線性迴歸分析和相關分析相結閤方法探討TF、TFPI與糖尿病腦梗死患者病情嚴重程度的關繫。結果：NIHSS評分≤12分組TF、TFPI、TF／TFPI、膽固醇和甘油三酯均顯著低于NIHSS評分＞12分組，差異有統計學意義（均P＜0.01）；NIHSS評分與TF（r＝0.354，P＝0.012）、TFPI（r＝0.302，P＝0.027）、TF／TFPI（r＝0.410，P＝0.000）、膽固醇（r＝0.364，P＝0.006）和甘油三酯（ r＝0.334，P＝0.018）顯著正相關；多元線性迴歸分析，結果錶明TF、TFPI、TF／TFPI、膽固醇為糖尿病腦梗死患者病情嚴重程度的獨立危險因素（ P＜0.05）。結論：急性期血清TF和TFPI可能與糖尿病腦梗死患者的病情嚴重程度相關。
목적：탐토조직인자（ TF）、조직인자도경억제물（ TFPI）재당뇨병뇌경사급성기적변화급여병정엄중정도적관계。방법：이당뇨병뇌경사환자위연구대상，이미국국립위생연구원졸중평분（ NIHSS）평개병정엄중정도，이단인소분석、다원선성회귀분석화상관분석상결합방법탐토TF、TFPI여당뇨병뇌경사환자병정엄중정도적관계。결과：NIHSS평분≤12분조TF、TFPI、TF／TFPI、담고순화감유삼지균현저저우NIHSS평분＞12분조，차이유통계학의의（균P＜0.01）；NIHSS평분여TF（r＝0.354，P＝0.012）、TFPI（r＝0.302，P＝0.027）、TF／TFPI（r＝0.410，P＝0.000）、담고순（r＝0.364，P＝0.006）화감유삼지（ r＝0.334，P＝0.018）현저정상관；다원선성회귀분석，결과표명TF、TFPI、TF／TFPI、담고순위당뇨병뇌경사환자병정엄중정도적독립위험인소（ P＜0.05）。결론：급성기혈청TF화TFPI가능여당뇨병뇌경사환자적병정엄중정도상관。
Objective:To explore the relationship between tissue factor (TF),tissue factor pathway inhibitor (TFPI) and the severity in patients with diabetic cerebral infarction.Methods: 226 patients with diabetic cerebral infarction were included into the study,National Institute of Health Stroke Scale ( NIHSS) was used to evaluate the severity of CIS.The single factor analysis and multiple regression analysis were used to explore the relationship between TF , TFPI and the severity.Results: The concentrations of TF,TFPI,TF/TFPI,cholesterol and triglyceride in the NIHSS≤12 group were significantly lower than that in the NIHSS>12 group ( P<0.05);the NIHSS was significantly positive correlate with TF (r=0.354,P=0.012),TFPI (r=0.302,P=0.027),TF/TFPI (r=0.410,P=0.000),cholesterol (r=0.364,P=0.006) and triglycerides (r=0.334,P=0.018);Multiple linear regression analysis showed that the TF , TFPI, TF/TFPI, cholesterol were independent risk factors of the severity in patients with diabetic cerebral infarction.Conclusion:The level of TF and TFPI could reflect the severity in patients with diabetic cerebral infarction according to the NIHSS.
