CAJ | 학술논문

目的：探讨MKK4蛋白在鼻咽癌组织中的表达及临床意义。方法：采用免疫组化方法分别检测90例鼻咽癌组织和20例鼻咽慢性炎症组织中MKK4蛋白的表达情况，并分析与鼻咽癌临床病理特征的关系。结果：MKK4蛋白在鼻咽癌组织中阳性表达率为75.6％（68／90），鼻咽慢性炎症组织中阳性表达率为95.5％（19／20），差异有统计学意义（ P＜0.05）。MKK4蛋白在有淋巴结转移、分化程度较差的组织中的高表达率明显低于无淋巴结转移、分化程度相对较好的组织（ P＜0.05），但不同年龄、性别、原发部位、T分期并不影响MKK4蛋白的阳性高表达率，无统计学差异（ P＞0.05）。结论：MKK4在鼻咽癌组织中的表达明显低于鼻咽慢性炎症组织中的表达，差异具有统计学意义；MKK4蛋白在有淋巴结转移、分化程度较差和临床分期较晚的组织中的表达明显低于无淋巴结转移、分化程度较好及临床分期较早的组织，差异具有显著性；但年龄、性别、原发部位、T分期在鼻咽癌组织中MKK4蛋白的表达均无显著性差异。
목적：탐토MKK4단백재비인암조직중적표체급림상의의。방법：채용면역조화방법분별검측90례비인암조직화20례비인만성염증조직중MKK4단백적표체정황，병분석여비인암림상병리특정적관계。결과：MKK4단백재비인암조직중양성표체솔위75.6％（68／90），비인만성염증조직중양성표체솔위95.5％（19／20），차이유통계학의의（ P＜0.05）。MKK4단백재유림파결전이、분화정도교차적조직중적고표체솔명현저우무림파결전이、분화정도상대교호적조직（ P＜0.05），단불동년령、성별、원발부위、T분기병불영향MKK4단백적양성고표체솔，무통계학차이（ P＞0.05）。결론：MKK4재비인암조직중적표체명현저우비인만성염증조직중적표체，차이구유통계학의의；MKK4단백재유림파결전이、분화정도교차화림상분기교만적조직중적표체명현저우무림파결전이、분화정도교호급림상분기교조적조직，차이구유현저성；단년령、성별、원발부위、T분기재비인암조직중MKK4단백적표체균무현저성차이。
Objective:To investigate the expression of MKK 4 protein in the nasopharyngeal carcinoma and its clinical significance.Methods:Immunohistochemical methods were employed to analyze MKK 4 positive expression intensity and positive cells in freshly collected nasopharyngeal carcinoma of both 90nasopharyngeal carcinoma cases and 20 chronic nasopharyngitis control.The clinical pathological characteristic were analyzed.Results:The data obtained by MKK4 immunohistochemistry showed that the MKK 4 positive rate was higher in control group than in the NPC group (95.5%vs 75.6%,P<0.05).The expression of MKK4 was related to tumor differentiation and lymph node metastasis ( P<0.05 ) , but not to gender , age, tumor volum and TNM stage ( P>0.05 ) . Conclusion:Positive rate of MKK4 protein in nasopharyngeal carcinoma tissues is lower than in chronic nasopharyngitis.MKK4 protein expressions in nasopharyngeal carcinoma tissues negatively correlated with lymph node metastasis ,clincal stage ,invasive depth ,and TTP (Time to progression),but not with age,gender,location and tumor volume.