CAJ | 학술논문

目的：研究miR-126在宫颈癌组织中的表达并探讨其临床意义。方法收集宫颈癌组织标本78例。采用qRT-PCR技术检测宫颈癌组织及癌旁正常宫颈组织中miR-126的表达情况，并分析miR-126在宫颈癌组织中的表达水平与宫颈癌患者临床病理参数之间的关系。结果 miR-126在宫颈癌组织中的表达相对于癌旁正常宫颈组织中的表达明显下调(P<0.001)。miR-126在宫颈癌组织中的高表达率与宫颈癌患者的组织分化程度、淋巴结转移以及临床分期明显相关，即miR-126在低分化组的高表达率明显低于高中分化组(P=0.013)，在有淋巴结转移组的高表达率明显低于无淋巴结转移组(P=0.005)，在Ⅲ~Ⅳ期组中的高表达率明显低于Ⅰ~Ⅱ期(P=0.007)。而miR-126在宫颈癌组织中的高表达率在不同年龄、肿瘤大小、HPV感染患者组之间比较差异均无统计学意义(P>0.05)。结论 miR-126可能参与宫颈癌的发生发展，检测miR-126的在宫颈癌中的表达对预测宫颈癌的浸润转移具有重要意义。
목적：연구miR-126재궁경암조직중적표체병탐토기림상의의。방법수집궁경암조직표본78례。채용qRT-PCR기술검측궁경암조직급암방정상궁경조직중miR-126적표체정황，병분석miR-126재궁경암조직중적표체수평여궁경암환자림상병리삼수지간적관계。결과 miR-126재궁경암조직중적표체상대우암방정상궁경조직중적표체명현하조(P<0.001)。miR-126재궁경암조직중적고표체솔여궁경암환자적조직분화정도、림파결전이이급림상분기명현상관，즉miR-126재저분화조적고표체솔명현저우고중분화조(P=0.013)，재유림파결전이조적고표체솔명현저우무림파결전이조(P=0.005)，재Ⅲ~Ⅳ기조중적고표체솔명현저우Ⅰ~Ⅱ기(P=0.007)。이miR-126재궁경암조직중적고표체솔재불동년령、종류대소、HPV감염환자조지간비교차이균무통계학의의(P>0.05)。결론 miR-126가능삼여궁경암적발생발전，검측miR-126적재궁경암중적표체대예측궁경암적침윤전이구유중요의의。
Objective To investigate the expression of miR-126 in cervical cancer and its clinical signifi-cance. Methods Expression of miR-126 was detected in 78 cases of cervical cancer by qRT-PCR. The correlations of miR-126 expression with clinicopathologic characteristics of cervical cancer patients were analyzed. Results The expression of miR-126 were significantly down-regulated in cervical cancer tissues than in the adjacent normal tis-sues. The difference was statistically significant (P<0.001). Decreased miR-126 expression in cervical cancer was found to be significantly associated with histological grade (P=0.013), lymph node metastasis (P=0.005), and the FI-GO stage (P=0.007). However, there was no statistically significant difference between the expression and age, tumor size, as well as HPV infection (P>0.05). Conclusion The expression of miR-126 may be involved in the occurrence and development of cervical cancer. Detection of miR-126 expression in cervical cancer is of great importance in the prediction of invasion and metastasis.