CAJ | 학술논문

目的：探讨血清可溶性P-选择素、可溶性E-选择素在糖尿病前期、单纯糖尿病期、糖尿病并发冠心病时期的水平变化及其促进2型糖尿病发生的机制。方法：32例正常对照组、32例糖尿病前期患者、32例单纯糖尿病期患者及34例糖尿病合并冠心病患者，用酶联免疫吸附法（ ELISA ）测定各组血清sP-选择素、sE-选择素的水平，同时测定体重指数（ BMI ）、血压（BP）、空腹血糖（FBG）、空腹胰岛素（FINS）、糖化血红蛋白（HbA1C）、甘油三脂（TG）、胆固醇（CHO）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、糖化血红蛋白（HbA1C）。结果：糖尿病前期组、单纯糖尿病组、糖尿病并发冠心病组sP-选择素、sE-选择素显著高于正常对照组（ P＜0.01）；血清sP-选择素、sE-选择素水平与FBG、FINS、TG、HbA1C、HOMA-IR呈明显正相关（P＜0.01）；sE-选择素与LDL-C呈负相关（P＜O.05）。结论：sP-选择素、sE-选择素在糖尿病前期组、单纯糖尿病组、糖尿病并发冠心病组是逐渐升高的，表明sP-选择素、sE-选择素是2型糖尿病发生的危险因素；sP-选择素、sE-选择素与HOMA-IR相关，提示sP-选择素、sE-选择素可能通过胰岛素抵抗促进2型糖尿病的发生。
목적：탐토혈청가용성P-선택소、가용성E-선택소재당뇨병전기、단순당뇨병기、당뇨병병발관심병시기적수평변화급기촉진2형당뇨병발생적궤제。방법：32례정상대조조、32례당뇨병전기환자、32례단순당뇨병기환자급34례당뇨병합병관심병환자，용매련면역흡부법（ ELISA ）측정각조혈청sP-선택소、sE-선택소적수평，동시측정체중지수（ BMI ）、혈압（BP）、공복혈당（FBG）、공복이도소（FINS）、당화혈홍단백（HbA1C）、감유삼지（TG）、담고순（CHO）、고밀도지단백（HDL-C）、저밀도지단백（LDL-C）、당화혈홍단백（HbA1C）。결과：당뇨병전기조、단순당뇨병조、당뇨병병발관심병조sP-선택소、sE-선택소현저고우정상대조조（ P＜0.01）；혈청sP-선택소、sE-선택소수평여FBG、FINS、TG、HbA1C、HOMA-IR정명현정상관（P＜0.01）；sE-선택소여LDL-C정부상관（P＜O.05）。결론：sP-선택소、sE-선택소재당뇨병전기조、단순당뇨병조、당뇨병병발관심병조시축점승고적，표명sP-선택소、sE-선택소시2형당뇨병발생적위험인소；sP-선택소、sE-선택소여HOMA-IR상관，제시sP-선택소、sE-선택소가능통과이도소저항촉진2형당뇨병적발생。
Objective:To explore the vailation of serum sP-selectin,sE-selectin,levels in the patients of pre-diabetic,simple type 2 diabetes mellitus (T2DM) and T2DM with coronary heartdisease(CAD).To investigate the possible mechanism that sP-selectin, sE-selectin accelerate type 2 diabetes mellitus.Methods: Level of serum sP-selectin, sE-selectin was assayed by ELISA in type 2 diabetes with or without coronary heart disease (32 and 34 cases respectively),pre-diabetic (32 cases) and control group(32 cases). Meanwhile BMI,BP,FBS,FINS,TG,CHO,HDL-C,LDL-C,HbA1C were determined in all cases as well as in control group.Results:The serum levels of sP-selectin and sE-selectin in pre-diabetic,type 2 diabetes mellitus with or without coronary heart disease groups were significantly higher than the control group ( P<0.01 ).There was significant positive correlation between serum levels of sP-selectin,sE-selectin and these items including FBG ,FINS,TG,HbA1C,HOMA-IR(P<0.01);but sE-selectin was negatively correlated with HDL-C (P<0.05).Conclusion:sP-selectin,sE-selectin,are risk factors in the initiation and progression of pre-diabetic,type 2 diabetes with or without coronary heart disease;sP-selectin and sE-selectin possibly accelerate type 2 diabetes by inducing insulin resist-ance.