中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2015年
16期
57-59
,共3页
前列地尔%贝那普利%糖尿病肾病%蛋白尿
前列地爾%貝那普利%糖尿病腎病%蛋白尿
전렬지이%패나보리%당뇨병신병%단백뇨
Alprostadil%Benazepril%Diabetic nephropathy%Proteinuria
目的：探讨前列地尔联合贝那普利治疗糖尿病肾病蛋白尿的临床疗效分析。方法选取2013年7月~2015年2月在本院治疗的糖尿病肾病患者65例，随机分为观察组33例及对照组32例。对照组给与贝那普利治疗，观察组在对照组基础上给与前列地尔治疗。对两组患者的临床疗效，24h尿蛋白含量与24h尿微白蛋白排泄率及不良反应情况进行比较。结果两组总有效率比较，观察组为93.94%，对照组为81.25%，两组比较，差异有统计学意义（P＜0.05）。与治疗前比较，治疗8周后两组患者的24h尿蛋白含量与24h尿微白蛋白排泄率明显降低（P＜0.05）；治疗后观察组的24h尿蛋白含量与24h尿微白蛋白排泄率明显低于对照组（P＜0.05）。总不良反应率，观察组为6.06%，对照组为9.39%，两组比较，差异无统计学意义（P＞0.05）。结论临床上对糖尿病肾病蛋白尿患者采用前列地尔联合贝那普利治疗，取的较好的临床疗效，且不良反应低。
目的：探討前列地爾聯閤貝那普利治療糖尿病腎病蛋白尿的臨床療效分析。方法選取2013年7月~2015年2月在本院治療的糖尿病腎病患者65例，隨機分為觀察組33例及對照組32例。對照組給與貝那普利治療，觀察組在對照組基礎上給與前列地爾治療。對兩組患者的臨床療效，24h尿蛋白含量與24h尿微白蛋白排洩率及不良反應情況進行比較。結果兩組總有效率比較，觀察組為93.94%，對照組為81.25%，兩組比較，差異有統計學意義（P＜0.05）。與治療前比較，治療8週後兩組患者的24h尿蛋白含量與24h尿微白蛋白排洩率明顯降低（P＜0.05）；治療後觀察組的24h尿蛋白含量與24h尿微白蛋白排洩率明顯低于對照組（P＜0.05）。總不良反應率，觀察組為6.06%，對照組為9.39%，兩組比較，差異無統計學意義（P＞0.05）。結論臨床上對糖尿病腎病蛋白尿患者採用前列地爾聯閤貝那普利治療，取的較好的臨床療效，且不良反應低。
목적：탐토전렬지이연합패나보리치료당뇨병신병단백뇨적림상료효분석。방법선취2013년7월~2015년2월재본원치료적당뇨병신병환자65례，수궤분위관찰조33례급대조조32례。대조조급여패나보리치료，관찰조재대조조기출상급여전렬지이치료。대량조환자적림상료효，24h뇨단백함량여24h뇨미백단백배설솔급불량반응정황진행비교。결과량조총유효솔비교，관찰조위93.94%，대조조위81.25%，량조비교，차이유통계학의의（P＜0.05）。여치료전비교，치료8주후량조환자적24h뇨단백함량여24h뇨미백단백배설솔명현강저（P＜0.05）；치료후관찰조적24h뇨단백함량여24h뇨미백단백배설솔명현저우대조조（P＜0.05）。총불량반응솔，관찰조위6.06%，대조조위9.39%，량조비교，차이무통계학의의（P＞0.05）。결론림상상대당뇨병신병단백뇨환자채용전렬지이연합패나보리치료，취적교호적림상료효，차불량반응저。
Objective To study the clinical effect of alprostadil combined benazepril in the treatment of diabetic renal proteinuria.Methods 65 patients with diabetic renal proteinuria, who were treated in our hospital from July 2013 to February 2015, were selected and randomly divided into observation group(33 cases) and control group(32 cases). To compare the clinical effect, the content of 24h urinary protein, 24h urinary microalbumin excretive rate, and the situation of adverse reaction between control group which was treated with benazepril and observation group which was treated with alprostadil combined benazepril.Results The differences of total effective rate between observation group(93.94%) and control group(81.25%) was statically significant(P<0.05). The content of 24h urinary protein, 24h urinary microalbumin excretive rate of the two groups after treatment 8 weeks were obviously lower than which before treatment(P<0.05), and after treatment, which in observation group was obviously lower than which in control group(P<0.05). The differences of the total adverse reaction rate between observation group(6.06%) and control group(9.39%) were no statically significant compared with(P>0.05).Conclusion Alprostadil combined benazepril in the treatment of diabetic renal proteinuria has better clinical effect and lower adverse reaction.
