中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2015年
16期
51-53,108
,共4页
眼干燥症%聚乙二醇%普拉洛芬%联合治疗
眼榦燥癥%聚乙二醇%普拉洛芬%聯閤治療
안간조증%취을이순%보랍락분%연합치료
Xerophthalmia%Polyethyleneglycol%Pranoprofen%Combined treatment
目的：观察聚乙二醇联合普拉洛芬滴眼液对眼干燥症的治疗效果。方法选取临床诊断为眼干燥症患者118例(236只眼)，随机分为观察组和对照组各59例。观察组给予4g/L聚乙二醇滴眼液联合使用1g/L普拉洛芬滴眼液，对照组单纯给予4g/L聚乙二醇滴眼液，用法均为每日4次，每次1滴，治疗1周。于治疗前后对患者进行自制症状量表评分，泪膜破裂时间（BUT）测定，基础泪液分泌试验（SIT）测定和角膜荧光素染色试验（FS）测定，并评定治疗的总有效率。结果观察组治疗后症状评分（9.46±1.27）分，与治疗前及对照组相比（P＜0.05）；观察组治疗后BUT（14.67±1.42）s，SIT（10.28±0.87）mm/5min，FS评分（1.06±0.37）分，与治疗前及对照组相比（P＜0.05）；观察组总有效率77.97％高于对照组57.63％，差异有统计学意义（P＜0.05）。结论聚乙二醇联合普拉洛芬滴眼液能够有效提高眼干燥症患者的治疗效果。
目的：觀察聚乙二醇聯閤普拉洛芬滴眼液對眼榦燥癥的治療效果。方法選取臨床診斷為眼榦燥癥患者118例(236隻眼)，隨機分為觀察組和對照組各59例。觀察組給予4g/L聚乙二醇滴眼液聯閤使用1g/L普拉洛芬滴眼液，對照組單純給予4g/L聚乙二醇滴眼液，用法均為每日4次，每次1滴，治療1週。于治療前後對患者進行自製癥狀量錶評分，淚膜破裂時間（BUT）測定，基礎淚液分泌試驗（SIT）測定和角膜熒光素染色試驗（FS）測定，併評定治療的總有效率。結果觀察組治療後癥狀評分（9.46±1.27）分，與治療前及對照組相比（P＜0.05）；觀察組治療後BUT（14.67±1.42）s，SIT（10.28±0.87）mm/5min，FS評分（1.06±0.37）分，與治療前及對照組相比（P＜0.05）；觀察組總有效率77.97％高于對照組57.63％，差異有統計學意義（P＜0.05）。結論聚乙二醇聯閤普拉洛芬滴眼液能夠有效提高眼榦燥癥患者的治療效果。
목적：관찰취을이순연합보랍락분적안액대안간조증적치료효과。방법선취림상진단위안간조증환자118례(236지안)，수궤분위관찰조화대조조각59례。관찰조급여4g/L취을이순적안액연합사용1g/L보랍락분적안액，대조조단순급여4g/L취을이순적안액，용법균위매일4차，매차1적，치료1주。우치료전후대환자진행자제증상량표평분，루막파렬시간（BUT）측정，기출루액분비시험（SIT）측정화각막형광소염색시험（FS）측정，병평정치료적총유효솔。결과관찰조치료후증상평분（9.46±1.27）분，여치료전급대조조상비（P＜0.05）；관찰조치료후BUT（14.67±1.42）s，SIT（10.28±0.87）mm/5min，FS평분（1.06±0.37）분，여치료전급대조조상비（P＜0.05）；관찰조총유효솔77.97％고우대조조57.63％，차이유통계학의의（P＜0.05）。결론취을이순연합보랍락분적안액능구유효제고안간조증환자적치료효과。
ObjectiveTo observe the curative effect of polyethyleneglycol combined with pranoprofen eye drops in the treatment of xerophthalmia. Methods118 patients (236 eyes) with xerophthalmia were randomly allocated to observation group and control group with 59 patients in each.The observation group received the treatment of 4g/L polyethyleneglycol eye drops and 1g/L pranoprofen eye drops while the control group only received 4g/L polyethyleneglycol eye drops.Both drugs were dropped for four times a day,and one drop a time,and the treatment lasted for a week.Patients were received a series of tests including scoring according to the self-made symptom checklist,tear film break-up time (BUT),Schirmer test (SIT) and Corneal Fluorescein Staining (FS) before and after the treatment.Total effective rate was calculated in the end.ResultsAfter treatment symptom score according to the self-made symptom checklist of the observation group was (9.46±1.27) compared with the scores before treatment and that of control group(P<0.05).BUT,SIT and FS score of the observation group were (14.67±1.42)s,(10.28±0.87)mm/5min and (1.06±0.37) respectively after treatment,all of which compared with those before treatment and in control group(P<0.05).Total effective rate of the observation group was 77.97%,which is higher than 57.63% in the control group,and the difference was statistically significant(P<0.05). Conclusion Polyethyleneglycol combined with pranoprofen eye drops can improve the curative effect in the treatment of xerophthalmia.
