CAJ | 학술논문

目的：制备厄贝沙坦缓释微丸，并对其体外释放度进行考察。方法采用流化床包衣技术，以丙烯酸树脂类Eudragit NE30D和Eudragit L30D-55混合水分散体为包衣材料，制备缓释微丸。考察不同释放介质、转速对其体外释药行为的影响。结果优化后的包衣处方为Eudragit NE30D/Eudragit L30D-55的比例为4︰1，抗粘剂和致孔剂的用量分别为聚合物干重的75%及20%，增重10%，熟化24h，释放介质的pH值对微丸释药的影响最明显，其体外释药过程符合一级释药模型。结论成功制备了厄贝沙坦缓释微丸，经考察其释放度符合要求。
목적：제비액패사탄완석미환，병대기체외석방도진행고찰。방법채용류화상포의기술，이병희산수지류Eudragit NE30D화Eudragit L30D-55혼합수분산체위포의재료，제비완석미환。고찰불동석방개질、전속대기체외석약행위적영향。결과우화후적포의처방위Eudragit NE30D/Eudragit L30D-55적비례위4︰1，항점제화치공제적용량분별위취합물간중적75%급20%，증중10%，숙화24h，석방개질적pH치대미환석약적영향최명현，기체외석약과정부합일급석약모형。결론성공제비료액패사탄완석미환，경고찰기석방도부합요구。
Objective To prepare irbesartan sustained-release pellets, and to investigate the in vitro release. MethodsTo prepare irbesartan sustained-release pellets by using of mini-fluidized bed spray coater with the aqueous dispersion coating material combined the acrylic resins of Eudragit NE30D and Eudragit L30D-55. To investigate the influence of different release medium and speed on drug release profile in vitro.Results The proportion of Eudragit NE30D/Eudragit L30D-55 in optimizational formula of coating was 4︰1, the amount of antisticking agent and pore-forming agent dry weight of polymer was respectively 75% and 20%, the weight had increased 10% with aging 24h. The pH of release medium has the most significantly influence, the process of in vitro release was accorded with first-order drug release model.ConclusionThe preparation of irbesartan sustained-release pellets is successful, and the in vitro release of which is meet the requirement.