CAJ | 학술논문

目的：研究分析持续泵注不同剂量右美托咪定缓解食管癌手术患者麻醉苏醒期副作用。方法选择2012年6月份到2014年6月份期间在我院进行手术治疗的60例食管癌患者为研究对象，将所选患者随机的分为观察1组，观察2组，以及对照组，每组各20例患者，给予观察组患者持续泵注不同剂量的右美托咪定，对照组泵注生理盐水，观察三组患者麻醉苏醒期副作用的缓解效果。结果观察1组的苏醒时间显著长于观察2组，且观察组在拔管时的MAP和HR显著升高，到五分钟后恢复至麻醉前状态，观察1组和观察2组的躁动时间和镇静评分显著优于对照组，差异具有统计学意义（P<0.05）。结论合理的选择右美托咪定的剂量和麻醉诱导前以及术中持续泵注的剂量，可以在有效的缓解食管癌手术患者麻醉苏醒期副作用的同时，有效的降低术后躁动，具有临床推广的应用价值。
목적：연구분석지속빙주불동제량우미탁미정완해식관암수술환자마취소성기부작용。방법선택2012년6월빈도2014년6월빈기간재아원진행수술치료적60례식관암환자위연구대상，장소선환자수궤적분위관찰1조，관찰2조，이급대조조，매조각20례환자，급여관찰조환자지속빙주불동제량적우미탁미정，대조조빙주생리염수，관찰삼조환자마취소성기부작용적완해효과。결과관찰1조적소성시간현저장우관찰2조，차관찰조재발관시적MAP화HR현저승고，도오분종후회복지마취전상태，관찰1조화관찰2조적조동시간화진정평분현저우우대조조，차이구유통계학의의（P<0.05）。결론합리적선택우미탁미정적제량화마취유도전이급술중지속빙주적제량，가이재유효적완해식관암수술환자마취소성기부작용적동시，유효적강저술후조동，구유림상추엄적응용개치。
ABSTRACT:Objective:To study the continuous infusion of different doses of dexmedetomidine will alleviate anesthesia recovery period of side effects in patients with esophageal carcinoma operation. Methods:choose June 2012 to 2014 during the month of June in our hospital for surgical treatment of 60 cases of esophageal cancer patients as the research object, the selected patients were randomLy divided into the observation group 1, were observed in the two groups, and control group, each 20 cases in each group, to give the patients in the observation group were continued infusion of not the same dose of dexmedetomidine set, control group infusion of saline observed three groups of patients with anesthesia recovery period of side effects of relieving effect. Results:observation group 1 recovery time was significantly longer than that in the two groups were observed, and the observation group extubation in map and HR were significantly increased, to five minutes after the return to anesthesia state, observation group and observation group 2 of agitation time and sedation score was significantly better than the control group, the difference has statistical significance (P<0.05). Conclusion: the reasonable choice of dexmedetomidine dose and before induction of anesthesia and intraoperative continued infusion at a dose of, can be in effectively relieve esophageal cancer surgery anesthesia recovery period of side effects at the same time, effectively reduce the restlessness, has clinical application value.