CAJ | 학술논문

目的：探讨红细胞分布宽度（RDW）对判断急性胰腺炎（AP）病情和预后的作用。方法63例 AP 患者被设为轻症 AP 组（35例）及重症 AP 组（28例），30名健康者被设为对照组。抽取患者就诊时和发病后72 h 及对照组的血液检测 RDW，对比轻症及重症 AP 患者以及 AP 患者与对照组 RDW 的差异，分析 RDW 与 AP 的病死率、局部并发症发生的关系。结果与对照组相比，AP患者就诊时的 RDW 较低[（14.1±2.1）％ vs.（16.8±2.3）％，P ＜0.001]；与轻症 AP 组相比，重症 AP 组就诊时的 RDW 更高[（14.9±1.9）％ vs.（19.2±2.4）％，P ＜0.001）]。死亡重症 AP 患者就诊时的 RDW 比存活者高[（24.2±4.1）％ vs.（18.6±2.3）％，P ＜0.001）]；发生局部并发症的轻型 AP 患者就诊时的 RDW 比无局部并发症者高[（23.9±3.2）％ vs.（18.2±2.3）％，P ＜0.001）]。结论RDW 可能是判断 AP 病情的潜在指标，与 AP 局部并发症和病死率可能相关。
목적：탐토홍세포분포관도（RDW）대판단급성이선염（AP）병정화예후적작용。방법63례 AP 환자피설위경증 AP 조（35례）급중증 AP 조（28례），30명건강자피설위대조조。추취환자취진시화발병후72 h 급대조조적혈액검측 RDW，대비경증급중증 AP 환자이급 AP 환자여대조조 RDW 적차이，분석 RDW 여 AP 적병사솔、국부병발증발생적관계。결과여대조조상비，AP환자취진시적 RDW 교저[（14.1±2.1）％ vs.（16.8±2.3）％，P ＜0.001]；여경증 AP 조상비，중증 AP 조취진시적 RDW 경고[（14.9±1.9）％ vs.（19.2±2.4）％，P ＜0.001）]。사망중증 AP 환자취진시적 RDW 비존활자고[（24.2±4.1）％ vs.（18.6±2.3）％，P ＜0.001）]；발생국부병발증적경형 AP 환자취진시적 RDW 비무국부병발증자고[（23.9±3.2）％ vs.（18.2±2.3）％，P ＜0.001）]。결론RDW 가능시판단 AP 병정적잠재지표，여 AP 국부병발증화병사솔가능상관。
Objective To investigate the clinical significance of red blood cell distribution width (RDW)in determining the disease severity and prognosis of patients with acute pancreatitis (AP).Methods A total of 63 patients with AP were divided into a mild AP group (35 patients)and a severe AP group (28 pa-tients);30 healthy volunteers were selected as the control group.Patient blood samples collected at the time of admission and 72 hours after disease onset,as well as control subject blood samples,were submitted for RDW determination.The RDW values were compared between the mild AP and severe AP patients and between AP patients and the control subjects to analyze the relationship between RDW and the mortality and occurrence of local complications in patients with AP.Results Compared to the control group,the AP patients exhibited a lower RDW value at the time of admission (1 4.1 % ±2.1 % vs.1 6.8% ±2.3%,P <0.001 ).Compared to the mild AP group,the severe AP group showed higher RDW values at the time of admission (1 4.9% ±1 .9%vs.1 9.2% ±2.4%,P <0.001 ).Among the patients with severe AP,those who died showed higher RDW values upon admission than those who survived (24.2% ±4.1 % vs.1 8.6% ±2.3%,P <0.001 ).In the mild AP group,the RDW values of the patients with local complications were higher than those without local complications (23.9% ±3.2% vs.1 8.2% ±2.3%,P <0.001 ).Conclusions RDW is a potential indica-tor of AP severity and might be related to the incidence of local complications and mortality in patients with AP.