CAJ | 학술논문

背景：国内外学者在主要致龋微生物因素上做了大量研究，但关于龋病致病因素仍未见全面而系统的评价。目的：对6种主要致龋微生物进行龋病致病因素的循证医学分析。方法：检索Cochrane图书馆、EMBASE、PubMed等外文数据库及万方数据库、中国生物医学文献数据库、中国期刊全文数据库、维普数据库等中文数据库中，2011至2014年之间发表的有关龋病病因微生物因素的相关文献，对符合条件的研究结果根据细菌A值范围分为观察组(较大A值)和对照组(较小A值)，对不同含量变形链球菌、乳酸杆菌、普氏菌属、月形单胞菌、二氧化碳嗜纤维菌属、韦荣球菌属影响下患龋病概率的统计学数据进行Meta分析。结果与结论：8篇文献符合纳入标准。OR值反映两组人群在相同致病因素下患病概率的统计差异，其值>1说明观察组龋病发生率大于对照组，<1说明观察组龋病发生率小于对照组。Meta分析结果显示，变形链球菌OR=2.41、乳酸杆菌OR=1.68、普氏菌属OR=2.75、二氧化碳嗜纤维菌属OR=1.98、月形单胞菌属OR=2.38，说明观察组患病概率大于对照组，反映了这些微生物与龋病的相关性较大，可能与龋病的发生发展有很大关系；韦荣球菌OR=0.45，说明观察组患病概率小于对照组，反映了韦荣球菌与龋病的相关性较小，可能在龋病某一发展阶段起到重要作用。
배경：국내외학자재주요치우미생물인소상주료대량연구，단관우우병치병인소잉미견전면이계통적평개。목적：대6충주요치우미생물진행우병치병인소적순증의학분석。방법：검색Cochrane도서관、EMBASE、PubMed등외문수거고급만방수거고、중국생물의학문헌수거고、중국기간전문수거고、유보수거고등중문수거고중，2011지2014년지간발표적유관우병병인미생물인소적상관문헌，대부합조건적연구결과근거세균A치범위분위관찰조(교대A치)화대조조(교소A치)，대불동함량변형련구균、유산간균、보씨균속、월형단포균、이양화탄기섬유균속、위영구균속영향하환우병개솔적통계학수거진행Meta분석。결과여결론：8편문헌부합납입표준。OR치반영량조인군재상동치병인소하환병개솔적통계차이，기치>1설명관찰조우병발생솔대우대조조，<1설명관찰조우병발생솔소우대조조。Meta분석결과현시，변형련구균OR=2.41、유산간균OR=1.68、보씨균속OR=2.75、이양화탄기섬유균속OR=1.98、월형단포균속OR=2.38，설명관찰조환병개솔대우대조조，반영료저사미생물여우병적상관성교대，가능여우병적발생발전유흔대관계；위영구균OR=0.45，설명관찰조환병개솔소우대조조，반영료위영구균여우병적상관성교소，가능재우병모일발전계단기도중요작용。
BACKGROUND:Scholars have carried out a lot of research on the main cariogenic microorganisms, but there is stil no comprehensive and systematic evaluation. OBJECTIVE:To perform an evidence-based medicine analysis on the six main cariogenic microorganisms. METHODS:Literature about microbial factors and age factors of caries disease etiology were retrieved, which were published from 2011 to 2014 in the Cochrane Library, EMBASE, PubMed, Wanfang, China Biology Medicine disc (CBMdisc), Chinese Journal Ful-text Database (CJFD) and VIP. Eligible studies were divided into two groups according to absorbance values: observation group (higher absorbance value) and control group (lower absorbance value). The probability of dental caries under the impact ofStreptococcus mutans, Lactobacilus microbe,Prevotela,Selenomonas,Capnocytophaga,Veilonelawere statisticaly analyzed using Meta-analysis. RESULTS AND CONCLUSION:Eight articles were included in result analysis. Odds ratio (OR) values refer to the statistical difference in the probability of dental caries under same pathogenic factors between two groups:OR > 1 indicates the incidence of dental caries is higher in the observation group than the control group, andOR < 1 suggests the incidence of dental caries is lower in the observation group than the control group. Meta-analysis results showStreptococcus mutans (OR=2.41),Lactobacilus microbe (OR=1.68),Prevotela (OR=2.75),Capnocytophaga (OR=1.98),Selenomonas(OR=2.38), indicating that the probability of dental caries is higher in the observation group than the control group, and these microorganisms are greatly correlated with the occurrence and development of dental caries;Veilonela (OR=0.45), indicating the probability of dental caries is lower in the observation group than the control group, andVeilonela has smal correlation with dental caries and only plays an important role in a certain development stage of dental caries.