CAJ | 학술논문

背景：血管内栓塞材料相继产出并应用于临床，在应用中不断出现新问题，对栓塞材料也不断提出新要求。目的：回顾性分析各类栓塞材料的应用及其优缺点，探讨其应用领域与栓塞材料的选择之间的相关性，为临床治疗提供参考。方法：检索中国知网和PubMed数据库中相关文献资料，结合有关栓塞材料临床应用及实验研究的文献进行了系统评价。包括各种栓塞材料的栓塞机制、优缺点及临床应用状况，并指出了目前研究中存在的问题，展望了未来研究的发展方向及临床的应用前景。结果与结论：栓塞材料应具有生物可降解性和生物可相容性。目前，临床使用的栓塞材料有可吸收明胶海绵、聚乙烯醇颗粒栓塞剂、微弹簧圈以及液体栓塞材料，明胶栓塞材料优点在于无抗原性、组织相容性好、取材制备方便有优良的可压缩性和遇水再膨胀性。聚乙烯醇颗粒是一种高分子材料，不溶于水，膨胀系数高，机械式栓塞血管，无致敏反应，无全身急性毒性，无皮内刺激反应，使用安全有效。液体栓塞材料中黏附性液体栓塞材料不具有血管毒性，得到了广泛的应用。血管内栓塞材料相继产出并应用于临床，在应用中不断出现新问题，对栓塞材料也不断提出新要求。因此，各种栓塞材料均有各自的优缺点，没有一种栓塞材料能适用于所有病变，选择合适的栓塞材料对安全有效的治疗非常重要。
배경：혈관내전새재료상계산출병응용우림상，재응용중불단출현신문제，대전새재료야불단제출신요구。목적：회고성분석각류전새재료적응용급기우결점，탐토기응용영역여전새재료적선택지간적상관성，위림상치료제공삼고。방법：검색중국지망화PubMed수거고중상관문헌자료，결합유관전새재료림상응용급실험연구적문헌진행료계통평개。포괄각충전새재료적전새궤제、우결점급림상응용상황，병지출료목전연구중존재적문제，전망료미래연구적발전방향급림상적응용전경。결과여결론：전새재료응구유생물가강해성화생물가상용성。목전，림상사용적전새재료유가흡수명효해면、취을희순과립전새제、미탄황권이급액체전새재료，명효전새재료우점재우무항원성、조직상용성호、취재제비방편유우량적가압축성화우수재팽창성。취을희순과립시일충고분자재료，불용우수，팽창계수고，궤계식전새혈관，무치민반응，무전신급성독성，무피내자격반응，사용안전유효。액체전새재료중점부성액체전새재료불구유혈관독성，득도료엄범적응용。혈관내전새재료상계산출병응용우림상，재응용중불단출현신문제，대전새재료야불단제출신요구。인차，각충전새재료균유각자적우결점，몰유일충전새재료능괄용우소유병변，선택합괄적전새재료대안전유효적치료비상중요。
BACKGROUND:Endovascular embolization materials have been produced and used clinicaly, but new problems constantly occur in the clinical application and new demands are also developed for embolic materials. OBJECTIVE:To retrospectively analyze the advantages and disadvantages of various types of embolic materials and to investigate the relationship between application fields and selection of embolic materials, thereby providing a reference for clinical treatment. METHODS:CNKI and PubMed databases were retrieved for relevant literature, and then embolic materials were systemicaly reviewed based on relevant clinical application and basic research literature in the folowing aspects: embolism mechanisms, clinical applications, advantages and disadvantages of various embolic materials. In this review, the existing problems in the current study were pointed out, and the development direction of relevant research and clinical application were also prospected. RESULTS AND CONCLUSION:Embolic materials should have biodegradability and biocompatibility. Current embolic materials include absorbable gelatin sponge, Polyvinylalcohol embolic agent, micro-coils and liquid embolic materials. Gelatin embolic material has no antigenicity and good histocompatibility, as wel as has excelent compressibility and water re-expansibility. Polyvinylalcohol particles are a polymer material that is insoluble in water, has high expansion coefficient, mechanical embolization, non-alergenic reaction, no acute systemic toxicity, no intracutaneous irritation, and can be used safely and effectively. Adhesive liquid embolic material has no vascular toxicity and has been widely used. Endovascular embolization materials have been produced in succession, and meanwhile, new problems in clinical applications have been found and new demands for embolic materials have been put forward continuously. Thus, a variety of embolic materials have their own advantages and disadvantages, and none of embolic materials can be applied to al diseases. To select an appropriate embolic material is very important for safe and effective treatment.