CAJ | 학술논문

成功制备出高品质的三元AgInS2量子点。通过配体交换法将油溶性AgInS2量子点转为水溶性量子点，通过dBSA修饰水溶性量子点形成配位体壳，使量子点具有更好的稳定性(4周)。从透射电子显微镜( TEM)观察到dBSA修饰后的量子点的粒径增加，分散性较好，并且在可见光区域有明显的光致发光。用叶酸对dBSA-MPA量子点进行修饰，并通过傅立叶变换红外光谱进行了验证。将得到的FA-dBSA-MPA纳米复合材料应用于能与叶酸受体特异性结合的乳腺癌细胞中，并在荧光倒置显微镜中检测到量子点成功对乳腺癌细胞进行了标记。与dBSA-MPA量子点相比，表面被叶酸修饰后的量子点与癌细胞的结合效率显著提高。
성공제비출고품질적삼원AgInS2양자점。통과배체교환법장유용성AgInS2양자점전위수용성양자점，통과dBSA수식수용성양자점형성배위체각，사양자점구유경호적은정성(4주)。종투사전자현미경( TEM)관찰도dBSA수식후적양자점적립경증가，분산성교호，병차재가견광구역유명현적광치발광。용협산대dBSA-MPA양자점진행수식，병통과부립협변환홍외광보진행료험증。장득도적FA-dBSA-MPA납미복합재료응용우능여협산수체특이성결합적유선암세포중，병재형광도치현미경중검측도양자점성공대유선암세포진행료표기。여dBSA-MPA양자점상비，표면피협산수식후적양자점여암세포적결합효솔현저제고。
AgInS2 quantum dots ( QDs) were synthesized using hot colloidal method and transferred into water via a ligand exchange route. To enhance the stability of these QDs, dBSA was coated on the aqueous QDs as a ligand shell. After dBSA modification, a size increase was observed from the transmission electron microscopy ( TEM) re-sults. The prepared dBSA-MPA QDs exhibited good monodispersity, enhanced stability ( stable for 4 weeks) and bright photoluminescence. Then the QDs were functionalized with folic acid ( FA) and the successful conjugation was confirmed by the Fourier transform infrared ( FT-IR) spectroscopy. The resulting FA-dBSA-MPA QDs nanocomposites were tested in breast cancer cells ( MCF-7 cells) with elevated folate receptor expression. Compared to the unconju-gated dBSA-MPA QDs, the presence of FA on the surface of QDs significantly improved the uptake rate of the nanop-articles by the cancer cells.