中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2015年
34期
5463-5467
,共5页
生物材料%纳米材料%纳米羟基磷灰石%聚酰胺66%股骨头坏死%修复%骨移植%髓芯减压
生物材料%納米材料%納米羥基燐灰石%聚酰胺66%股骨頭壞死%脩複%骨移植%髓芯減壓
생물재료%납미재료%납미간기린회석%취선알66%고골두배사%수복%골이식%수심감압
Hydroxyapatites%Nylons%Femur Head Necrosis
背景：纳米羟基磷灰石复合聚酰胺66材料具有良好的材料-细胞界面，拥有三维孔洞网络结构，在植入人体后还可以随着时间的推移逐渐降解。目的：观察纳米羟基磷灰石复合聚酰胺66材料修复早期股骨头坏死的效果。方法：纳入62例早期股骨头坏死患者，其中男32例，女30例，年龄34-51岁，均分为2组治疗，观察组进行纳米羟基磷灰石复合聚酰胺66材料植入联合髓芯减压植骨治疗，对照组进行钽棒置入联合髓芯减压植骨治疗。对比两组治疗后1 d疼痛情况，治疗后随访12个月，对比两组髋关节功能Harris评分。结果与结论：治疗后1 d，两组疼痛目测类比评分比较差异无显著性意义。观察组治疗后3，12个月的髋关节功能Harris评分高于对照组(P <0.05)，两组均未发生与修复材料相关的不良反应。表明利用纳米羟基磷灰石复合聚酰胺66材料修复早期股骨头坏死具有良好的生物相容性，并可促进患者肢体功能恢复。
揹景：納米羥基燐灰石複閤聚酰胺66材料具有良好的材料-細胞界麵，擁有三維孔洞網絡結構，在植入人體後還可以隨著時間的推移逐漸降解。目的：觀察納米羥基燐灰石複閤聚酰胺66材料脩複早期股骨頭壞死的效果。方法：納入62例早期股骨頭壞死患者，其中男32例，女30例，年齡34-51歲，均分為2組治療，觀察組進行納米羥基燐灰石複閤聚酰胺66材料植入聯閤髓芯減壓植骨治療，對照組進行鐽棒置入聯閤髓芯減壓植骨治療。對比兩組治療後1 d疼痛情況，治療後隨訪12箇月，對比兩組髖關節功能Harris評分。結果與結論：治療後1 d，兩組疼痛目測類比評分比較差異無顯著性意義。觀察組治療後3，12箇月的髖關節功能Harris評分高于對照組(P <0.05)，兩組均未髮生與脩複材料相關的不良反應。錶明利用納米羥基燐灰石複閤聚酰胺66材料脩複早期股骨頭壞死具有良好的生物相容性，併可促進患者肢體功能恢複。
배경：납미간기린회석복합취선알66재료구유량호적재료-세포계면，옹유삼유공동망락결구，재식입인체후환가이수착시간적추이축점강해。목적：관찰납미간기린회석복합취선알66재료수복조기고골두배사적효과。방법：납입62례조기고골두배사환자，기중남32례，녀30례，년령34-51세，균분위2조치료，관찰조진행납미간기린회석복합취선알66재료식입연합수심감압식골치료，대조조진행단봉치입연합수심감압식골치료。대비량조치료후1 d동통정황，치료후수방12개월，대비량조관관절공능Harris평분。결과여결론：치료후1 d，량조동통목측류비평분비교차이무현저성의의。관찰조치료후3，12개월적관관절공능Harris평분고우대조조(P <0.05)，량조균미발생여수복재료상관적불량반응。표명이용납미간기린회석복합취선알66재료수복조기고골두배사구유량호적생물상용성，병가촉진환자지체공능회복。
BACKGROUND:Nano-hydroxyapatite/polyamide 66 composite has good material-cel interface and three-dimensional porous network structure, and it can also be gradualy degraded over time after implantation in the human body. OBJECTIVE:To explore the effect of nano-hydroxyapatite/polyamide 66 in early repair of femoral head necrosis. METHODS:A retrospective analysis was performed on clinical data of 62 cases of early osteonecrosis of the femoral head, including 32 males and 30 females, aged 34-51 years. These patients were divided into control group (31 cases) and observation group (31 cases) according to treatment methods. Core decompression with nano-hydroxyapatite/polyamide 66 implantation and core decompression with bone graft were respectively performed in the observation and control groups. Incidence of pain in the two groups was compared at 1 day after treatmen; and during the 12-month folow-up, the Harris score of the hip function in the two groups was compared. RESULTS AND CONCLUSION:There was no significant difference in the visual analog scale scores between two groups at 1 day after treatment. The Harris scores in the observation group were significantly higher than those in the control group at 3 and 12 months after treatment (P < 0.05). There was no adverse reaction in the two groups. These findings indicate that nano-hydroxyapatite/polyamide 66 material for repair of early femoral head necrosis has good biocompatibility, and can obtain good effects on limb function recovery.
