华东理工大学学报：社会科学版
華東理工大學學報：社會科學版
화동리공대학학보：사회과학판
SOCIAL SCIENCES JOURNAL OF ECUST
2006年
5期
~
,共null页
杨晓玲 韩霄 答鸿 朱以华 李春忠
楊曉玲 韓霄 答鴻 硃以華 李春忠
양효령 한소 답홍 주이화 리춘충
层层自组装 核壳式微球 含磁药物胶囊 载药
層層自組裝 覈殼式微毬 含磁藥物膠囊 載藥
층층자조장 핵각식미구 함자약물효낭 재약
layer-by-layer self-assembly; core-shell microspheres; magnetic polyelectrolyte DOX capsules; drug loading;
以低度交联的单分散三聚氰胺甲醛(M F)微球作为胶体模板,采用层层静电自组装技术,交替组装带正电的聚二烯丙基二甲基氯化铵(PDDA)和带负电的聚4-苯乙烯磺酸钠(PSS),得到具有核壳结构的复合微球,然后利用盐酸溶液将模板M F微球溶解,制得均匀的空腔胶囊。在N aC l浓度为0.7 m o l/L,pH<3时,将抗癌药物盐酸多柔米星(DOX)和磁流体同时封装到聚电解质胶囊中,可得到含磁药物胶囊,磁性粒子分散在胶囊的壳层和空腔内。该含磁药物胶囊具有良好的磁响应性和药物缓释性。
以低度交聯的單分散三聚氰胺甲醛(M F)微毬作為膠體模闆,採用層層靜電自組裝技術,交替組裝帶正電的聚二烯丙基二甲基氯化銨(PDDA)和帶負電的聚4-苯乙烯磺痠鈉(PSS),得到具有覈殼結構的複閤微毬,然後利用鹽痠溶液將模闆M F微毬溶解,製得均勻的空腔膠囊。在N aC l濃度為0.7 m o l/L,pH<3時,將抗癌藥物鹽痠多柔米星(DOX)和磁流體同時封裝到聚電解質膠囊中,可得到含磁藥物膠囊,磁性粒子分散在膠囊的殼層和空腔內。該含磁藥物膠囊具有良好的磁響應性和藥物緩釋性。
이저도교련적단분산삼취청알갑철(M F)미구작위효체모판,채용층층정전자조장기술,교체조장대정전적취이희병기이갑기록화안(PDDA)화대부전적취4-분을희광산납(PSS),득도구유핵각결구적복합미구,연후이용염산용액장모판M F미구용해,제득균균적공강효낭。재N aC l농도위0.7 m o l/L,pH<3시,장항암약물염산다유미성(DOX)화자류체동시봉장도취전해질효낭중,가득도함자약물효낭,자성입자분산재효낭적각층화공강내。해함자약물효낭구유량호적자향응성화약물완석성。
Uniform hollow capsules were produced by layer-by-layer electrostatic self-assembly technique.The core-shell microspheres were constructed by alternately depositing negative and positive polyelectrolyte onto the weakly-crosslinked melamine formaldehyde(MF) microspheres which were used as the colloidal templates, then the templates were dissolved by 0.1 mol/L hydrochloric acid and hollow capsules came into being.The anti-cancer drug dexorubicin hydrochloride(DOX) and magnetic fluid were encapsulate in the ho...
