CAJ | 학술논문

以三苯基氯甲烷和乙酸酐依次对蔗糖的8个羟基进行选择性保护,考察了反应配比、温度、溶剂对蔗糖保护过程的影响。结果表明:以吡啶替代二甲基甲酰胺(DMF)和N-甲基吗啉作为溶剂和缚酸剂的伯羟基醚化反应,选择性为78%,三苯甲醇收率达98%以上,以甲苯为萃取剂和乙酰化反应的溶剂,避免了除杂过程的液固分离和固固分离,反应平稳,催化剂可循环使用,蔗糖全基团保护物(TRISPA)的收率达到75%。
이삼분기록갑완화을산항의차대자당적8개간기진행선택성보호,고찰료반응배비、온도、용제대자당보호과정적영향。결과표명:이필정체대이갑기갑선알(DMF)화N-갑기마람작위용제화박산제적백간기미화반응,선택성위78%,삼분갑순수솔체98%이상,이갑분위췌취제화을선화반응적용제,피면료제잡과정적액고분리화고고분리,반응평은,최화제가순배사용,자당전기단보호물(TRISPA)적수솔체도75%。
Selective hydroxyl protected reaction of sucrose by trityl chloride and acetic anhydride was investigated.The intluence of solvent,temperature and mole ratio of material on the protected process were discussed.The results show that using pyridine as solvent and removal acid reagent instead of DMF and N-methylmorpholine,the selectivity of 6,1′,6′-ether sucrose is 78% and the yield of tritonal is more than 98%.After extraction with toluene,the catalyst can be recycled and the reaction is stable,the yield of T...