CAJ | 학술논문

采用大鼠急性束缚应激动物模型,用鹅羔氨酸损毁大鼠双侧内嗅皮质来建立内嗅皮质损伤模型,观察束缚应激1小时后下丘脑室旁核快反应基因c-Fos表达情况以及应激后血浆促肾上腺皮质激素含量的动态变化,并与对照组相比较,探讨内嗅皮质与束缚应激反应的关系.结果表明,损毁内嗅皮质,明显抑制了应激诱导的下丘脑室旁核c-Fos的表达和血浆促肾上腺皮质激素含量的上升.结果提示,内嗅皮质参与调节束缚应激反应时HPA轴功能.
채용대서급성속박응격동물모형,용아고안산손훼대서쌍측내후피질래건립내후피질손상모형,관찰속박응격1소시후하구뇌실방핵쾌반응기인c-Fos표체정황이급응격후혈장촉신상선피질격소함량적동태변화,병여대조조상비교,탐토내후피질여속박응격반응적관계.결과표명,손훼내후피질,명현억제료응격유도적하구뇌실방핵c-Fos적표체화혈장촉신상선피질격소함량적상승.결과제시,내후피질삼여조절속박응격반응시HPA축공능.
This study was designed to determine the effect of the entorhinal cortex on stress response to immobilization in rats.Neurons in the entorhinal cortex were lesioned by bilateral injection of the cell-selective neurotoxin, ibotenic acid （ 1.5μg/μl of solution per side）. Two weeks later, rats were subjected to immobilization stress. Rats in which ibotenic acid had been injected into the entorhinal cortex showed attenuated expression of c-Fos in the hypothalamic paraventricular nucleus （PVN） and blunted elevation of plasma adrenocorticotropic hormone （ACTH） after immobilization stress compared with rats in which saline had been injected into the entorhinal cortex. The results of this study indicate that the entorhinal cortex is closely involved in the activation of the HPA axis during immobilization stress in rats.