CAJ | 학술논문

对递增负荷运动及恢复不同阶段大鼠下丘脑及垂体组织细胞的超微结构进行了透射电镜观察，发现在长期递增负荷运动训练过程中，大鼠下丘脑弓状核神经元出现渐进性的细胞器变性、轴突髓鞘分离、突触小泡及微管微丝减少、树突棘减少等异常变化，垂体促性腺细胞及生长激素细胞出现渐进性的细胞器变性及核膜异常，溶酶体增多等，而ACTH细胞形态结构变化较小，与同期测定的较低FSH、IH水平和较高CRH及GC水平具有一致性。结果表明，长期训练可致大鼠脑组织神经元间的相互联系减弱，促性腺激素释放激素的合成及分泌均受到抑制。这种变化与训练周期的增长及运动负荷的增大具有显著递进关系。而经过4个动情周期的恢复，结构逐渐复原，为一可逆性变化过程。
대체증부하운동급회복불동계단대서하구뇌급수체조직세포적초미결구진행료투사전경관찰，발현재장기체증부하운동훈련과정중，대서하구뇌궁상핵신경원출현점진성적세포기변성、축돌수초분리、돌촉소포급미관미사감소、수돌극감소등이상변화，수체촉성선세포급생장격소세포출현점진성적세포기변성급핵막이상，용매체증다등，이ACTH세포형태결구변화교소，여동기측정적교저FSH、IH수평화교고CRH급GC수평구유일치성。결과표명，장기훈련가치대서뇌조직신경원간적상호련계감약，촉성선격소석방격소적합성급분비균수도억제。저충변화여훈련주기적증장급운동부하적증대구유현저체진관계。이경과4개동정주기적회복，결구축점복원，위일가역성변화과정。
The aims of this experiment were to elucidate the potential mechanisms of effects of structure changes on functions in rats＇ hypothalamus and pituitary during prngressive increasing training load and recovery courses. Transmission electron microscope was used to observe the tissue ultrastructure. The major results＇were： Gradually, organelles denaturalized, myelin sheath of axons separated, synapse vesicles, microtubule, microneme, and dendritic spine reduced in the neurons of areuate hypothalamic nucleus in rats during training courses. Organelles denaturalized and nuclear membrane was abnormal, lysosomes increased in gonadotroph（Gn） and somatotroph （GH）cells, but ultrastructure less changed in corticotroph（ACTH）cells in pituitary. These ultrastructure changes were consistent in lower gonadotrophin, and higher CRH and GC levels in the same phase. These results suggested that connections of neurons weakened, GnRH synthesizing and secreting were disturbed in hypothalamus and pituitary during long - term training, and this changes related to training period and training load volume. The structure changes were progressively recovered after 4 estrous cycles rest.