CAJ | 학술논문

通过在不同负荷的运动训练状态下，观察大鼠血清BUN、Scr、尿蛋白排泄率以及肾组织TGF-β1表达的变化，研究不同负荷的运动训练对大鼠肾组织结构、功能及肾组织TGF-β1表达的影响，以及揭示肾组织TGF-β1的表达对肾脏组织结构、功能变化及运动性蛋白尿产生的作用及机制。实验结果表明：综过8周过度训练后，大鼠血清BUN、Scr及尿TP排泄率显著升高（P〈0．05），肾组织TGF-β1表达明显增加，表明过度训练造成肾小球及肾小管超微结构的伤害，随着ECM过度堆积，发生肾间质纤维化，加剧肾单位的损害，导致肾小球滤过和肾小管重吸收功能的下降。提示过度训练导致肾组织TGF-β1表达的显著增加，是过度训练造成肾组织超微结构及功能损害的重要因素。
통과재불동부하적운동훈련상태하，관찰대서혈청BUN、Scr、뇨단백배설솔이급신조직TGF-β1표체적변화，연구불동부하적운동훈련대대서신조직결구、공능급신조직TGF-β1표체적영향，이급게시신조직TGF-β1적표체대신장조직결구、공능변화급운동성단백뇨산생적작용급궤제。실험결과표명：종과8주과도훈련후，대서혈청BUN、Scr급뇨TP배설솔현저승고（P〈0．05），신조직TGF-β1표체명현증가，표명과도훈련조성신소구급신소관초미결구적상해，수착ECM과도퇴적，발생신간질섬유화，가극신단위적손해，도치신소구려과화신소관중흡수공능적하강。제시과도훈련도치신조직TGF-β1표체적현저증가，시과도훈련조성신조직초미결구급공능손해적중요인소。
This research was designed to observe the effects of different training load on renal structure , function , and the expression of transforming growth factorβ1（TGF-β1） in renal tissue, and to explore the effects of the expression of TGF-β1, in renal tissue on renal structure and function, as well as on the exercise - induced Urinary Protein. Serum BuN, Scr , urinary TP excretion and expression of TGF-β1 were tested immediately after 8-week training at different training load. The results indicated that after overtraining, serum BUN, Scr and urinary protein excretion rate increased significantly. The expression of TGF-β1 in renal tissue increased significantly. It showed that overtraining resulted in the damage of TGF-β1 were tested immediately after 8 weeks training at different training load. The results indicated that after overtraining, serum BUN, Scr and urinary protein excretion rate increased significantly. The expressinon of TGF-β1 in renal tissue increased significantly. It showed that overtraining resulted in the damage of the normal structure and function of renal glomerulus and tubular. As the over--accumulation of exrtalellular matrix （ECM）, enhanced the expression of TGF-β1 in kidney. It can be seen as an important factor in the damage to renal microstructuare and fumction caused by over-training.