体育科学
體育科學
체육과학
China Sport Science
2007年
1期
72~75
,共null页
安玉香 夏书红 刘金海 王岸新
安玉香 夏書紅 劉金海 王岸新
안옥향 하서홍 류금해 왕안신
水杨酸钠 抗疲劳 剂量 鼠 动物实验
水楊痠鈉 抗疲勞 劑量 鼠 動物實驗
수양산납 항피로 제량 서 동물실험
sodium salicylate ; anti-fatigue ; dosage ; mice ; animal experiment
目的：研究微量水杨酸钠对小鼠的抗疲劳作用及其量效关系。方法：将54只昆明种雄性小鼠随机分为6个组，对照组（腹腔注射等体积生理盐水）、实验Ⅰ组（按10mg／kg腹腔注射水杨酸钠）、实验Ⅱ组（按20mg／kg腹腔注射水杨酸钠）、实验Ⅲ组（按30mg／kg腹腔注射水杨酸钠）、实验Ⅳ组（按40mg／kg腹腔注射水杨酸钠）和实验Ⅴ组（按50mg／kg腹腔注射水杨酸钠），每组9只。记录给药后120min每只小鼠的负重游泳时间，仔细观察小鼠一般游泳状态的变化，测定游泳前、后血中乳酸含量。结果：用药剂量在10mg／kg～40mg／kg之间，水杨酸钠可明显延长负重游泳时间、提高游泳速度、减小乳酸堆积（P〈0．01），存在剂量效应关系，当用药剂量增至50mg／kg时，药物效应开始下降，只能延长负重游泳时间（P〈0.01）、轻度减小乳酸堆积（P〈0．05），不能提高游泳速度。结论；微量水杨酸钠对小鼠运动性疲劳有明显的干预作用，水杨酸钠抗疲劳作用的阅剂量为10mg／kg，最大效应剂量为40mg／kg。
目的：研究微量水楊痠鈉對小鼠的抗疲勞作用及其量效關繫。方法：將54隻昆明種雄性小鼠隨機分為6箇組，對照組（腹腔註射等體積生理鹽水）、實驗Ⅰ組（按10mg／kg腹腔註射水楊痠鈉）、實驗Ⅱ組（按20mg／kg腹腔註射水楊痠鈉）、實驗Ⅲ組（按30mg／kg腹腔註射水楊痠鈉）、實驗Ⅳ組（按40mg／kg腹腔註射水楊痠鈉）和實驗Ⅴ組（按50mg／kg腹腔註射水楊痠鈉），每組9隻。記錄給藥後120min每隻小鼠的負重遊泳時間，仔細觀察小鼠一般遊泳狀態的變化，測定遊泳前、後血中乳痠含量。結果：用藥劑量在10mg／kg～40mg／kg之間，水楊痠鈉可明顯延長負重遊泳時間、提高遊泳速度、減小乳痠堆積（P〈0．01），存在劑量效應關繫，噹用藥劑量增至50mg／kg時，藥物效應開始下降，隻能延長負重遊泳時間（P〈0.01）、輕度減小乳痠堆積（P〈0．05），不能提高遊泳速度。結論；微量水楊痠鈉對小鼠運動性疲勞有明顯的榦預作用，水楊痠鈉抗疲勞作用的閱劑量為10mg／kg，最大效應劑量為40mg／kg。
목적：연구미량수양산납대소서적항피노작용급기량효관계。방법：장54지곤명충웅성소서수궤분위6개조，대조조（복강주사등체적생리염수）、실험Ⅰ조（안10mg／kg복강주사수양산납）、실험Ⅱ조（안20mg／kg복강주사수양산납）、실험Ⅲ조（안30mg／kg복강주사수양산납）、실험Ⅳ조（안40mg／kg복강주사수양산납）화실험Ⅴ조（안50mg／kg복강주사수양산납），매조9지。기록급약후120min매지소서적부중유영시간，자세관찰소서일반유영상태적변화，측정유영전、후혈중유산함량。결과：용약제량재10mg／kg～40mg／kg지간，수양산납가명현연장부중유영시간、제고유영속도、감소유산퇴적（P〈0．01），존재제량효응관계，당용약제량증지50mg／kg시，약물효응개시하강，지능연장부중유영시간（P〈0.01）、경도감소유산퇴적（P〈0．05），불능제고유영속도。결론；미량수양산납대소서운동성피로유명현적간예작용，수양산납항피노작용적열제량위10mg／kg，최대효응제량위40mg／kg。
The purpose of this study was to analyze dose-effects relationship about anti-fatigue of sodium salicylate with micro dose of mice. Fifty-four Kunming mice were randomly divided into control group, experimental group Ⅰ, group Ⅱ, group Ⅲ, group Ⅳ and group Ⅴ, nine mice for each group, which were respectively given peritoneal injection with physiological saline and sodium salicylate at 10mg/kg, 20mg/kg, 30mg/kg, 40mg/kg and 50mg/kg. After 120 minutes, the loaded-swimming time was recorded, the situation of swimming was observed. The concentration of blood lactic acid （BLA）was measured. The result showed that when the dose at 10mg/kg to 40mg/kg, the loaded-swimming time was significantly prolonged, the swimming speed significantly increased and the accumulation of blood lactic acid significantly reduced than those in the control group（P〈0.01）. There existed dose-effects relationship. When the dose increased to 50mg/kg, the effects come to reduce and only the loaded-swimming time prolonged. The reduction of accumulation of blood lactic acid can be neglected. It concluded that the threshold dose of sodium salicylate on anti-fatigue effects was at 10mg/kg and the maximum efficacy dose at 40mg/kg. It suggested that the sodium salicylate definitely improved the anti-fatigue with small dose.
