CAJ | 학술논문

现已发现肌酸进行跨膜转运需要相应的转运体（包括细胞膜运载体和线粒体运载体）是肌酸在体内分布的关键因素之一；肌酸的转运与转运体的数量及其表达、骨骼肌纤维的类型、Na^＋和Cl^-浓度、激素、运动等多因素相关；肌酸在机体内代谢并分解为肌酸酐并且经肾脏排除体外；肌酸代谢动力学研究涉及到血药最大浓度（Cmax）和达到最大浓度的时间（Tmax）等动力学参数。
현이발현기산진행과막전운수요상응적전운체（포괄세포막운재체화선립체운재체）시기산재체내분포적관건인소지일；기산적전운여전운체적수량급기표체、골격기섬유적류형、Na^＋화Cl^-농도、격소、운동등다인소상관；기산재궤체내대사병분해위기산항병차경신장배제체외；기산대사동역학연구섭급도혈약최대농도（Cmax）화체도최대농도적시간（Tmax）등동역학삼수。
The result shows that it is known that there are two main kinds of Cr transporters （CrTs）, one is plasmalemma CrT and the other is mitochondrial CrT which affects the distribution of Cr. Cr uptake across the plasma membrane by CrT relating to the quantity of CrT and its expression, different skeletal muscle fiber types, the of Na ^＋ and Cl^-, hormone, exercises and so on. Cr is converted into creatiulne（Crn） that constantly diffuses out of the tissues into the blood and is excreted by the kidneys into the urine. Some researches on pharmacokinetics has examined the behaviors of Cr in blood, such as a concentration of maximal plasma （Cmax） and a time of maximal plasma （Tmax）.