CAJ | 학술논문

为验证谷氨酸（Glu）能神经和卜氨基丁酸（GABA）能神经之间的相互作用可能是有氧运动改变自主神经平衡状态的中枢机制之一，以正常大鼠为实验对象，以8周中等强度的游泳运动为干预手段，观察比较两组大鼠Glu能神经和GABA能神经免疫阳性产物在心血管自主神经中枢各核团内的表达情况，以及脑脊液中氨基酸类神经递质的变化。研究结果提示，长期参加有氧运动可通过下列中枢途径改变自主神经的平衡状态：降低下丘脑室旁核内Glu能神经纤维密度，增加GABA能神经纤维密度，从而改变下丘脑室旁核交感兴奋性神经元的“兴奋一抑制”平衡，表现为抑制性作用加强；改变孤柬核和疑核内兴奋性神经元和抑制性神经元的比例，从而增强应激状态下自主神经对心血管反射的调节能力或加强安静状态下的迷走神经紧张性；通过增加CVLM向RVLM投射的GABA能神经纤维，从而加强对RVLM内交感节前神经元的抑制；通过脑脊液中的氨基酸类神经递质含量的变化，对触液神经元的功能产生影响，从而影响心血管自主神经的平衡状态。
위험증곡안산（Glu）능신경화복안기정산（GABA）능신경지간적상호작용가능시유양운동개변자주신경평형상태적중추궤제지일，이정상대서위실험대상，이8주중등강도적유영운동위간예수단，관찰비교량조대서Glu능신경화GABA능신경면역양성산물재심혈관자주신경중추각핵단내적표체정황，이급뇌척액중안기산류신경체질적변화。연구결과제시，장기삼가유양운동가통과하렬중추도경개변자주신경적평형상태：강저하구뇌실방핵내Glu능신경섬유밀도，증가GABA능신경섬유밀도，종이개변하구뇌실방핵교감흥강성신경원적“흥강일억제”평형，표현위억제성작용가강；개변고간핵화의핵내흥강성신경원화억제성신경원적비례，종이증강응격상태하자주신경대심혈관반사적조절능력혹가강안정상태하적미주신경긴장성；통과증가CVLM향RVLM투사적GABA능신경섬유，종이가강대RVLM내교감절전신경원적억제；통과뇌척액중적안기산류신경체질함량적변화，대촉액신경원적공능산생영향，종이영향심혈관자주신경적평형상태。
In order to test the hypothesis on interaction between glutamatergic nerves and gabaergic nerves contribute to the changing balance state of autonomic nerve, ordinary SD rats were divided into training group and control group. The training group undertook 8-week swimming exercise and observed and compared expression of glutamatergic nerves and gabaergic nerves by immunohistochemical method and amino acids neurotransmitter in cerebrospinal fluid by automatic amino acid analyzer. The results showed that the long-term aerobic exercise can change the balance state of cardiovascular autonomic nerve system, decrease glutamatergic nerves and increase gabaergic nerves in paraventricular hypothalamic nucleus （PVN）, which will enhance sympathetic inhibition. Change the proportion of excitatory neuron and inhibitory neuron in nucleus tractus solitarii （NTS） and nucleus ambiguus （NA）, which may enhance regulative ability of cardiovascular autonomic nerve to stress state, or increase vagal tone in resting state, increase gabaergic nerves fiber in caudal ventrolateral medulla （CVLM） projected to rostral ventrolateral medulla （RVLM）, which can enhance inhibition effect on sympathetic preganglionic neuron in RVLM. Change the content of amino acids neurotransmitter in cerebrospinal fluid to influence ambient autonomic neuron.