CAJ | 학술논문

目前，人们研究肿瘤的热点已经从癌基因转到抑癌基因，在已发现的数个抑癌基因中，p53、Fas、p16、Fhit、nm23、BLCAP与宫颈癌的关系密切，也是宫颈癌研究的热点．p53和p16基因通过调控细胞周期来抑制细胞增殖；Fas通过与其配体FasL或其单克隆抗体结合后，诱导Fas所在细胞凋亡；Fhit通过诱导细胞凋亡、细胞周期阻滞发挥着抑制肿瘤细胞增殖的作用；nm23则是通过改变nm23基因的编码产物二磷酸核苷酸激酶（NDPK）从而引起NTP产生不足，参与浸润、转移过程；BLCAP是一个新近发现的宫颈癌相关抑癌基因，其功能及性质尚不大清楚．
목전，인문연구종류적열점이경종암기인전도억암기인，재이발현적수개억암기인중，p53、Fas、p16、Fhit、nm23、BLCAP여궁경암적관계밀절，야시궁경암연구적열점．p53화p16기인통과조공세포주기래억제세포증식；Fas통과여기배체FasL혹기단극륭항체결합후，유도Fas소재세포조망；Fhit통과유도세포조망、세포주기조체발휘착억제종류세포증식적작용；nm23칙시통과개변nm23기인적편마산물이린산핵감산격매（NDPK）종이인기NTP산생불족，삼여침윤、전이과정；BLCAP시일개신근발현적궁경암상관억암기인，기공능급성질상불대청초．
At present, researchers have now focused on the part from oncogenes to suppressor genes in the field of tumor study. The p53, fas, p16, Fhit, nm23 and BLCAP are suppressor genes most related to the Cervical Carcinoma among several suppressor genes that have been discovered, and also the most emphasized parts in Cervical Carcinoma research. The p53 and p16 gene can inhibit cell multiplication by controlling cell＇s mitotic cycle; the Fas gene can combine with its ligand FasL or its monoclonal antibody and induce the cell in which it is to death; the Fhit gene can suppress the cell multiplication by inducing the cell to death or blocking the cell circle; meanwhile, gene nm23 causes insufficient production of nucleoside triphosphate （NTP） that participates in soakage and transaction procedure by modifying genome encoding product nucleoside-diphosphate kinase （NDPK）; but so far the functionality and characteristic of the suppressor gene BLCAP which is discovered recently remains unknown.