CAJ | 학술논문

壳聚糖（CS）作载体，与三聚磷酸钠（TPP）和5-氟尿嘧啶（5-Fu）发生离子交联反应，制备具有缓释效能的5-氟尿嘧啶壳聚糖纳米微球，并以微球载药量、颗粒大小为指标设计优化了其制备方法，考察不同因数水平对微球的载药量的影响。用傅立叶红外光谱表征了其结构，用激光散射粒径仪测得微球的平均粒径为143～212nm。氟尿嘧啶壳聚糖微球最大载药量为48．3％，在pH7．1磷酸盐缓冲溶液中对氟尿嘧啶的缓释作用明显，释放周期较长，药物含量越大，药物从微球中释放出来的速率越快，可作为靶向药物控释体系。
각취당（CS）작재체，여삼취린산납（TPP）화5-불뇨밀정（5-Fu）발생리자교련반응，제비구유완석효능적5-불뇨밀정각취당납미미구，병이미구재약량、과립대소위지표설계우화료기제비방법，고찰불동인수수평대미구적재약량적영향。용부립협홍외광보표정료기결구，용격광산사립경의측득미구적평균립경위143～212nm。불뇨밀정각취당미구최대재약량위48．3％，재pH7．1린산염완충용액중대불뇨밀정적완석작용명현，석방주기교장，약물함량월대，약물종미구중석방출래적속솔월쾌，가작위파향약물공석체계。
The antitumor drugs 5 -Fu- CS nanoparticles have been formed based on ionic gelation process of tripolyphosphate （TPP）, 5 - Fu and chitosan. In order to gain the best parameters for preparing nanoparticles, the influences of different factors on average drug loading efficiency and particle size were evaluated by single - factor designing method. The physicochemical properties of nanoparticles were investigated in detail by using FTIR, UV Vis spectra, and laser dynamic scattering analysis. The average drug loading efficiency was 47.1% and the mean particle size was 143 ～ 212 nm. The release characteristics of the nanoparticles were studied in phosphate buffer solution. The results indicate that chitosan may be useful as a carrier for sustained release of drugs.