北京体育大学学报
北京體育大學學報
북경체육대학학보
Journal of Beijing University of Physical Education
2008年
1期
50~52
,共null页
张洪海 王人卫 黄雅君 檀志宗
張洪海 王人衛 黃雅君 檀誌宗
장홍해 왕인위 황아군 단지종
动情周期 促肾上腺皮质激素 促甲状腺激素释放激素 促甲状腺激素 催乳素
動情週期 促腎上腺皮質激素 促甲狀腺激素釋放激素 促甲狀腺激素 催乳素
동정주기 촉신상선피질격소 촉갑상선격소석방격소 촉갑상선격소 최유소
estrum; ACTH; PRL; TRH; TSH
为研究递增运动负荷对大鼠下丘脑-垂体-肾上腺轴（HPA）与下丘脑-垂体-甲状腺轴（HPT）激素的影响，进一步探讨运动性月经失调（AMI）和HPA、HPT轴激素变化的关系。将成熟、健康的两月龄雌性SD大鼠35只随机分为5组进行研究，结果发现：1）随着运动负荷递增，ACTH、PRL、TRH、TSH的水平逐渐升高，Ta组大鼠阴道中底层细胞数量逐周增加，第七周最高；2）Ta组血ACTH、PRL与C组相比，存在显著性差异（P〈0.05）；Ta组血TSH和C组相比，存在显著性差异（P〈0.01）；Tb组血TRH和C组相比，存在显著性差异（P〈0.01）。恢复一周后，ACTH、TRH的水平均有所下降。3）经过7周的递增负荷训练，Ta组大鼠肾上腺重量明显高于C组（P〈0.01），休息一周后略有恢复，但仍高于C组（P〈0.05）；Ta组大鼠甲状腺重量明显低于C组（P〈0.01）。结论：1）长期大强度运动导致HPA轴高度活化，肾上腺功能亢进，诱导AMI发生。2）长期大强度运动导致HPT轴功能紊乱，甲状腺功能减退，诱导AMI发生。3）提示：AMI是多器官多系统交互作用的结果，HPA轴高度活化、HPT轴功能紊乱及PRL水平升高均可导致AMI的发生。
為研究遞增運動負荷對大鼠下丘腦-垂體-腎上腺軸（HPA）與下丘腦-垂體-甲狀腺軸（HPT）激素的影響，進一步探討運動性月經失調（AMI）和HPA、HPT軸激素變化的關繫。將成熟、健康的兩月齡雌性SD大鼠35隻隨機分為5組進行研究，結果髮現：1）隨著運動負荷遞增，ACTH、PRL、TRH、TSH的水平逐漸升高，Ta組大鼠陰道中底層細胞數量逐週增加，第七週最高；2）Ta組血ACTH、PRL與C組相比，存在顯著性差異（P〈0.05）；Ta組血TSH和C組相比，存在顯著性差異（P〈0.01）；Tb組血TRH和C組相比，存在顯著性差異（P〈0.01）。恢複一週後，ACTH、TRH的水平均有所下降。3）經過7週的遞增負荷訓練，Ta組大鼠腎上腺重量明顯高于C組（P〈0.01），休息一週後略有恢複，但仍高于C組（P〈0.05）；Ta組大鼠甲狀腺重量明顯低于C組（P〈0.01）。結論：1）長期大彊度運動導緻HPA軸高度活化，腎上腺功能亢進，誘導AMI髮生。2）長期大彊度運動導緻HPT軸功能紊亂，甲狀腺功能減退，誘導AMI髮生。3）提示：AMI是多器官多繫統交互作用的結果，HPA軸高度活化、HPT軸功能紊亂及PRL水平升高均可導緻AMI的髮生。
위연구체증운동부하대대서하구뇌-수체-신상선축（HPA）여하구뇌-수체-갑상선축（HPT）격소적영향，진일보탐토운동성월경실조（AMI）화HPA、HPT축격소변화적관계。장성숙、건강적량월령자성SD대서35지수궤분위5조진행연구，결과발현：1）수착운동부하체증，ACTH、PRL、TRH、TSH적수평축점승고，Ta조대서음도중저층세포수량축주증가，제칠주최고；2）Ta조혈ACTH、PRL여C조상비，존재현저성차이（P〈0.05）；Ta조혈TSH화C조상비，존재현저성차이（P〈0.01）；Tb조혈TRH화C조상비，존재현저성차이（P〈0.01）。회복일주후，ACTH、TRH적수평균유소하강。3）경과7주적체증부하훈련，Ta조대서신상선중량명현고우C조（P〈0.01），휴식일주후략유회복，단잉고우C조（P〈0.05）；Ta조대서갑상선중량명현저우C조（P〈0.01）。결론：1）장기대강도운동도치HPA축고도활화，신상선공능항진，유도AMI발생。2）장기대강도운동도치HPT축공능문란，갑상선공능감퇴，유도AMI발생。3）제시：AMI시다기관다계통교호작용적결과，HPA축고도활화、HPT축공능문란급PRL수평승고균가도치AMI적발생。
The research was conducted to investigate changes of Hypothalamo-Pituitary-Adrena （HPA） and Hypothalamo-Pituitary-Thyroid （HPT） hormones in incremental graded exercise, as well as the relation between changes of hormones 35 adults and healthy female SD rats were randomly divided into 5 groups. The experiments shows that： 1. The desquamated middle and bottom level cells of vagina increased week by week and reached the highest at seventh week in rats of Ta group; 2. With the increase of exercise load,the level of ACTH,PRL,TRH and TSH increased gradually. ACTH and PRL of Ta group were significantly different with C group （ P 〈0.05 ）;TSH of Ta group were significantly different with C group （ P 〈0.01 ）;TRH of Tb group were significantly different with C group （ P 〈0.01 ）. After 1 week recovery, ACTH and TRH decreased significantly; 3. With the increase of exercise load, the weight of adrenal increased, Ta group were significantly different with C group （P 〈 0.01）;The weight of thyroid decreased, the weight of thyroid of Ta group were significantly different with C group（ P 〈0.05 ）, after 1 week recovery, the weight of thyroid increased significantly. Conclusions are： 1. The results suggest that high intensity training conduced to excitation of HPA and adrenal, which induced to AMI; 2. The results suggest that high intensity training conduced to turbulence of HPT and depression of thyroid,which induced to AMI; 3. The results indicate that AMI was a result of interaction of many systems,excitation of HPA,turbulence of HPT and increase of PRL way induce to AMI.
