CAJ | 학술논문

NMDA受体是一类离子型谷氨酸受体，其功能主要参与发育过程中神经回路的细化及触发多种形式的突触可塑性。近年来的证据表明，组成NMDA受体的亚单位有着复杂的生理学和药理学特性；NMDA受体的数量、分布和亚单位组成并非一成不变，而是在发育过程中、神经元活动时，以一种细胞特异性和突触特异性的方式变化着。这种NMDA受体的双向变化是突触可塑性重塑的基础，而其调节的异常又可导致神经．精神疾病的发生，如可卡因成瘾、精神分裂症等。
NMDA수체시일류리자형곡안산수체，기공능주요삼여발육과정중신경회로적세화급촉발다충형식적돌촉가소성。근년래적증거표명，조성NMDA수체적아단위유착복잡적생이학화약이학특성；NMDA수체적수량、분포화아단위조성병비일성불변，이시재발육과정중、신경원활동시，이일충세포특이성화돌촉특이성적방식변화착。저충NMDA수체적쌍향변화시돌촉가소성중소적기출，이기조절적이상우가도치신경．정신질병적발생，여가잡인성은、정신분렬증등。
Within the large family of excitatory ionotropie glutamate receptors （iGluRs）, N-methyl-D-aspartate receptors （NMDARs） constitute a subfamily which involved in refinement of the neural circuits during development and various forms of synaptie plasticity. In recent years, increasing evidence indicates that different NMDA receptor subunits confer complex physiological and pharmacological properties. The number, distribution and subunit composition of NMDA receptors are not static but dynamic in a cell-specific and synaptie specific change during development and neuronal activities. The bi-direetional changes in NMDA receptors are the basis of synaptie plasticity remodeling, and the abnormal regulation can lead to the occurrence of nerve - mental illness, such as cocaine addiction and schizophrenia.