CAJ | 학술논문

氟是人体必需的微量元素，但摄入过量能引起骨相系统损害。流行病学和动物实验结果表明，长期过量氟暴露还能损害中枢神经系统，从而损伤动物的学习记忆力和儿童的智商。自由基损伤伤学说可能是氟致脑损伤的机理之一。而硒也是人类必需的微量元素之一，动物实验结果表明，适量硒能拮抗氟致脑功能的损伤，其机理可能与硒的抗氧化性的生物学功能有关。
불시인체필수적미량원소，단섭입과량능인기골상계통손해。류행병학화동물실험결과표명，장기과량불폭로환능손해중추신경계통，종이손상동물적학습기억력화인동적지상。자유기손상상학설가능시불치뇌손상적궤리지일。이서야시인류필수적미량원소지일，동물실험결과표명，괄량서능길항불치뇌공능적손상，기궤리가능여서적항양화성적생물학공능유관。
Fluoride is a trace element which human body need, but it can arouse injure on bone System if one who have taken in too much. Epidemiology and results of animals experiment show that it can lead to impairment of central nervous system when exposure to high doses of fluoride occurs for prolonged period of time, then hazard to in learning and memory of animals and the intelligence quotient of children. The free-radical theory may be an important factor in connection with the mechanism of the brain dysfunction due to chronic fluorosis. Selenium（Se） is an essential trace element, results of animals experiment provide evidence that proper concentration of Se might antagonize brain impairment caused by fluoride toxicity, its mechanism may be based on the biological function of antioxidant capacity of Se.