CAJ | 학술논문

采用吲哚美辛、幽门结扎法制作小鼠和大鼠急性胃溃疡模型，观察并比较川芎与雷尼替丁抗实验性胃溃疡的效果。结果显示，川芎撮物（5g·kg^-1和10g·kg^-1）可使两种模型动物的胃溃疡发生率降低，溃疡减轻，溃疡面积明显减小，并能使幽门结扎大鼠的胃液量减少，胃液pH值提高，溃疡抑制率达61．5％以上。川芎组与生理盐水组比较具有明显差异（P〈0．01）；与雷尼替丁的作用无显著性差异（P〉0.05）。以上结果表明，川芎对动物实验性胃溃疡有明显的抑制作用，其作用可能与减少胃液和胃酸的分泌，增加胃粘膜的保护作用有关。
채용신타미신、유문결찰법제작소서화대서급성위궤양모형，관찰병비교천궁여뢰니체정항실험성위궤양적효과。결과현시，천궁촬물（5g·kg^-1화10g·kg^-1）가사량충모형동물적위궤양발생솔강저，궤양감경，궤양면적명현감소，병능사유문결찰대서적위액량감소，위액pH치제고，궤양억제솔체61．5％이상。천궁조여생리염수조비교구유명현차이（P〈0．01）；여뢰니체정적작용무현저성차이（P〉0.05）。이상결과표명，천궁대동물실험성위궤양유명현적억제작용，기작용가능여감소위액화위산적분비，증가위점막적보호작용유관。
The objective is to observe the effects of Rhizoma Chuanxiong on the experimental gastric ulcer. The methods are as follows： the different preventive effects of Rhizoma Chuanxiong and ranitidine are observed and compared in treating acute gastric ulcer mode caused by indomethacin and pyloric ligation. The results are as follows ： the Rhizoma Chuanxiong at 5 g · kg^-1 to 10 g · kg^-1 could significantly inhibit gastric ulcer formation, remarkably reduce the area of gastric ulcer and the gastric volume, and increase the gastric pH. The inhibition rate of the Rhizoma Chuanxiong exceeds 61.5%. There is significant difference between the Rhizoma Chuanxiong and physiological saline （P 〈0.05 ）. There is no significant difference between the Rhizoma Chuanxiong and ranitidine （ P 〉 0. 05 ）. Therefore, the following conclusion is reached： the Rhizoma Chuanxiong could inhibit the experimental gastric ulcer obviously, which may relate to decreasing the secretion of gastric juice and gastric acid and strengthening the mucosal defensive action.