心理科学进展
心理科學進展
심이과학진전
Advances In Psychological Science
2009年
1期
126~131
,共null页
条件性恐惧记忆 消退 情绪性增强效应 二级条件化 再巩固 内侧前额叶皮层
條件性恐懼記憶 消退 情緒性增彊效應 二級條件化 再鞏固 內側前額葉皮層
조건성공구기억 소퇴 정서성증강효응 이급조건화 재공고 내측전액협피층
conditioned fear memory; extinction; emotional enhancing effect; secondary-order conditioning; reconsolidation; medial prefrontal cortex
创伤后应激障碍是个体经历严重应激后形成的一种焦虑障碍,对其治疗的关键是消退由创伤应激导致的条件性恐惧记忆,但目前最有效的暴露疗法并不能真正有效地抑制患者恐惧记忆的表达。对条件性恐惧的动物模型研究发现情绪性增强效应、恐惧记忆二级条件化与再巩固、内侧前额叶皮层功能不足等均能够阻碍条件性恐惧记忆的消退。针对这几个方面可以探索治疗创伤后应激障碍的相应方法。
創傷後應激障礙是箇體經歷嚴重應激後形成的一種焦慮障礙,對其治療的關鍵是消退由創傷應激導緻的條件性恐懼記憶,但目前最有效的暴露療法併不能真正有效地抑製患者恐懼記憶的錶達。對條件性恐懼的動物模型研究髮現情緒性增彊效應、恐懼記憶二級條件化與再鞏固、內側前額葉皮層功能不足等均能夠阻礙條件性恐懼記憶的消退。針對這幾箇方麵可以探索治療創傷後應激障礙的相應方法。
창상후응격장애시개체경력엄중응격후형성적일충초필장애,대기치료적관건시소퇴유창상응격도치적조건성공구기억,단목전최유효적폭로요법병불능진정유효지억제환자공구기억적표체。대조건성공구적동물모형연구발현정서성증강효응、공구기억이급조건화여재공고、내측전액협피층공능불족등균능구조애조건성공구기억적소퇴。침대저궤개방면가이탐색치료창상후응격장애적상응방법。
Posttraumatic stress disorder is a kind of anxiety disorder which developed after severe trauma. The key of treatment for this disorder is to extinct the conditioned fear memory acquired in trauma. But the most effective exposure therapy can＇t repress fear memory efficiently. Researches from animal model of fear conditioning showed that： enhancing effects of emotional arousal, secondary-order conditioning and reconsolidation of fear memory, deficient function of medial prefrontal cortex etc all are reasons block the extinction of fear memory. According to these reasons, corresponding treatment ways can be explored and developed.
