应用心理学
應用心理學
응용심이학
Chinese JOurnal of Applied Psychology
2008年
2期
99~103
,共null页
石金富 袁艺 邹枝玲 李祖贵 袁飞 张宝华 李静薇 沈模卫 翁旭初
石金富 袁藝 鄒枝玲 李祖貴 袁飛 張寶華 李靜薇 瀋模衛 翁旭初
석금부 원예 추지령 리조귀 원비 장보화 리정미 침모위 옹욱초
海洛因成瘾 灰质密度 用药年限
海洛因成癮 灰質密度 用藥年限
해락인성은 회질밀도 용약년한
heroin addiction, gray matter density, duration of drug use
本研究对海洛因成瘾者（n=34）和无毒品依赖的正常被试（n=34）进行磁共振脑结构扫描，用基于体素的形态学测量（VBM）方法分析被试间灰质密度的差异，并考察了海洛因成瘾者用药时间与灰质密度之间的关系。结果表明，同正常对照组相比，海洛因成瘾者其额叶和颞叶下部的灰质密度显著下降。进一步分析显示，用药时间短于5年的成瘾者其灰质密度下降不明显，而用药时间5年以上的患者其灰质密度下降非常显著。本文讨论了上述结果的潜在临床价值和理论意义。
本研究對海洛因成癮者（n=34）和無毒品依賴的正常被試（n=34）進行磁共振腦結構掃描，用基于體素的形態學測量（VBM）方法分析被試間灰質密度的差異，併攷察瞭海洛因成癮者用藥時間與灰質密度之間的關繫。結果錶明，同正常對照組相比，海洛因成癮者其額葉和顳葉下部的灰質密度顯著下降。進一步分析顯示，用藥時間短于5年的成癮者其灰質密度下降不明顯，而用藥時間5年以上的患者其灰質密度下降非常顯著。本文討論瞭上述結果的潛在臨床價值和理論意義。
본연구대해락인성은자（n=34）화무독품의뢰적정상피시（n=34）진행자공진뇌결구소묘，용기우체소적형태학측량（VBM）방법분석피시간회질밀도적차이，병고찰료해락인성은자용약시간여회질밀도지간적관계。결과표명，동정상대조조상비，해락인성은자기액협화섭협하부적회질밀도현저하강。진일보분석현시，용약시간단우5년적성은자기회질밀도하강불명현，이용약시간5년이상적환자기회질밀도하강비상현저。본문토론료상술결과적잠재림상개치화이론의의。
Thirty heroin addicts and 34 control participants were scanned with a 3T MRI scanner. Voxel-base Morphometry（VBM） was used to examine difference in grey matter density between the two groups. The heroin addicts were further divided into two groups according to years of drug usage, and were separately compared to the control group. Results showed that compared to the control group, the heroin addicts show decreased grey matter density in the frontal lobe and the temporal lobe. Further analysis revealed that only the heroin addicts who have used the drug for more than five years show significant decrease in the grey matter density, while those who have a drug use history shorter than five years do not. The practical and theoretical implications of these findings are also discussed.
