武汉体育学院学报
武漢體育學院學報
무한체육학원학보
Journal of Wuhan Institute of Physical Education
2009年
8期
51~54
,共null页
李蕾 李之俊 魏安奎 白洋
李蕾 李之俊 魏安奎 白洋
리뢰 리지준 위안규 백양
IR 动物模型 高脂膳食 运动干预 评价
IR 動物模型 高脂膳食 運動榦預 評價
IR 동물모형 고지선식 운동간예 평개
IR; animal model; high fat dietary; exercise intervention; evaluation
目的：建立IR动物模型和运动干预模型，为后续实验奠定基础。方法：46只雄性SD大鼠分4组：普食对照组、普食运动组、高脂膳食对照组、高脂膳食运动组。以高脂膳食诱导IR，同时运动组进行10周有氧游泳运动干预。综合利用体重、FINS、FBG、HOMA—IR、1S1、ITT指标评价动物模型的建立和运动干预的效果。结果：（1）E组和C组、H组和C组、HE组和H组间，体重、FINS和ISI有显著性著异（P〈0．01或P〈0．05）；（2）ITT中，0时血糖无差异，在15min、30min、60min时间点，H组明显高于C组，HE组明显低于H组（P〈0．05）。E组与C组比，15min、30min时明显下降（P〈0．05）。结论：高脂膳食饲养10周可诱导正常SD大鼠出现IR；运动提高了大鼠胰岛素敏感性：间接评价IR指标中ISl较HOMA—IR敏感。
目的：建立IR動物模型和運動榦預模型，為後續實驗奠定基礎。方法：46隻雄性SD大鼠分4組：普食對照組、普食運動組、高脂膳食對照組、高脂膳食運動組。以高脂膳食誘導IR，同時運動組進行10週有氧遊泳運動榦預。綜閤利用體重、FINS、FBG、HOMA—IR、1S1、ITT指標評價動物模型的建立和運動榦預的效果。結果：（1）E組和C組、H組和C組、HE組和H組間，體重、FINS和ISI有顯著性著異（P〈0．01或P〈0．05）；（2）ITT中，0時血糖無差異，在15min、30min、60min時間點，H組明顯高于C組，HE組明顯低于H組（P〈0．05）。E組與C組比，15min、30min時明顯下降（P〈0．05）。結論：高脂膳食飼養10週可誘導正常SD大鼠齣現IR；運動提高瞭大鼠胰島素敏感性：間接評價IR指標中ISl較HOMA—IR敏感。
목적：건립IR동물모형화운동간예모형，위후속실험전정기출。방법：46지웅성SD대서분4조：보식대조조、보식운동조、고지선식대조조、고지선식운동조。이고지선식유도IR，동시운동조진행10주유양유영운동간예。종합이용체중、FINS、FBG、HOMA—IR、1S1、ITT지표평개동물모형적건립화운동간예적효과。결과：（1）E조화C조、H조화C조、HE조화H조간，체중、FINS화ISI유현저성저이（P〈0．01혹P〈0．05）；（2）ITT중，0시혈당무차이，재15min、30min、60min시간점，H조명현고우C조，HE조명현저우H조（P〈0．05）。E조여C조비，15min、30min시명현하강（P〈0．05）。결론：고지선식사양10주가유도정상SD대서출현IR；운동제고료대서이도소민감성：간접평개IR지표중ISl교HOMA—IR민감。
Insulin resistant rats and exercise intervention models were built in order to set foundation for subsequent work. 46 rats were divided into normal dietary control group, normal exercise group, high fat dietary control group and high fat dietary exercise group. High fat dietary were fed and exercise group were given aerobic swimming intervention for ten weeks. Body weight, FINS, FBG, HOMA-IR, ISI and insulin tolerant test were used to evaluate building of animal model and effect of exercise intervention. It was shown that between E and C, H and C, HE and H groups, there were significant differences on body weight, FINS and ISI （p〈 0.01 or p〈0.05）. In IET, blood of H group was significantly higher than that of C and that of HE was lower than that of C （p〈 0.05） at 15min, 30min and 60min. Compared with E, C was lower at 15min and 30min. It could be seen that ten weeks of high fat dietary feeding induced IR in SD rats. Exercise enhanced rats insulin sensitivity and indirect evaluation of IR, ISI was more sensitive than HOMA-IR.
