CAJ | 학술논문

前额皮层去甲肾上腺素能神经支配主要来自脑干蓝斑核。前额皮层存在不同类型的肾上腺素能受体。其中突触后α2及β2肾上腺素能受体的激活提高工作记忆;α1及β1肾上腺素能受体的激活损害工作记忆。不同受体是通过激活不同的信号通路发挥对工作记忆的调节作用。来自人类被试的研究结果与对动物的研究结果之间尚存在不一致。了解前额皮层不同肾上腺素受体的作用为开发治疗与前额皮层功能失调相关疾病的药物提供了新的方向。
전액피층거갑신상선소능신경지배주요래자뇌간람반핵。전액피층존재불동류형적신상선소능수체。기중돌촉후α2급β2신상선소능수체적격활제고공작기억;α1급β1신상선소능수체적격활손해공작기억。불동수체시통과격활불동적신호통로발휘대공작기억적조절작용。래자인류피시적연구결과여대동물적연구결과지간상존재불일치。료해전액피층불동신상선소수체적작용위개발치료여전액피층공능실조상관질병적약물제공료신적방향。
Norepinephrinegic innervations in the prefrontal cortex mainly come from locus coeruleus at the brain stem. There are various types of adrenoceptors in the prefrontal cortex. The activations of post-synaptic α2 and β2 adrenoceptors improve the working memory, whereas the activation of α2 and β2 receptors impairs the performance of tasks that require working memory. The modulation of different types of adrenoceptors on the working memory is achieved by activating different signaling pathways. Some results coming from human subjects are not consistent with those from animals. A good understanding of the effects of various types of adrenoceptors on working memory will be a new direction in developing medicines for the treatment of dysfunction of prefrontal cortex.