CAJ | 학술논문

目的：探讨跑台运动对不同月龄大鼠空间学习和记忆的影响。方法：实验采用1月龄和13月龄Sprague-Dawley雄性大鼠，随机分为4组（n=10）：1月龄安静对照组、1月龄跑台运动组、13月龄安静对照组、13月龄跑台运动组，其中，跑台运动组大鼠以中等强度进行为期1周的跑台运动；然后使用Moms水迷宫，对各组大鼠的定位航行和空间探索能力进行分析。结果：在定位航行试验中，两个运动组大鼠寻找到平台的潜伏期要明显短于相应的安静对照组（P〈O．01）；1月龄跑台运动组大鼠的潜伏期要少于13月龄跑台运动组（P〈0．05）。在空间探索试验中，两个运动组大鼠在原平台象限探索时间百分比要明显多于其相应的安静对照组（P〈O．05）。此外，1月龄跑台运动组大鼠穿过原平台的次数明显多于其安静对照组（P〈0．05）和13月龄跑台运动组（P〈O．05）。13月龄大鼠的两组之间并无差异。结论：跑台运动可以促进大鼠的空间学习和记忆能力，而且，这种作用效果在幼龄期表现得更加明显。
목적：탐토포태운동대불동월령대서공간학습화기억적영향。방법：실험채용1월령화13월령Sprague-Dawley웅성대서，수궤분위4조（n=10）：1월령안정대조조、1월령포태운동조、13월령안정대조조、13월령포태운동조，기중，포태운동조대서이중등강도진행위기1주적포태운동；연후사용Moms수미궁，대각조대서적정위항행화공간탐색능력진행분석。결과：재정위항행시험중，량개운동조대서심조도평태적잠복기요명현단우상응적안정대조조（P〈O．01）；1월령포태운동조대서적잠복기요소우13월령포태운동조（P〈0．05）。재공간탐색시험중，량개운동조대서재원평태상한탐색시간백분비요명현다우기상응적안정대조조（P〈O．05）。차외，1월령포태운동조대서천과원평태적차수명현다우기안정대조조（P〈0．05）화13월령포태운동조（P〈O．05）。13월령대서적량조지간병무차이。결론：포태운동가이촉진대서적공간학습화기억능력，이차，저충작용효과재유령기표현득경가명현。
To investigate the effect of treadmill running on spatial learning and memory in different age of rats. Male Sprague-Dawley rats （1 month of age and 13 months of age） were used for the experiment, rats were randomly divided into the 1 month control group, 1 month running group, 13 month control group and 13 month running group （n= 10 in each group）. The running group was made to run on a motor driven treadmill for 1 week. Then the Morris water maze was used to observe learning and memory in rats of four groups. The result showed that, in place navigation training, the latency of rats in both running groups were less than that of rats in respectively control groups（P〈0.01） and the latency of rats in 1 month running group was less than that of rats in 13 month groups （P〈0.05）. In spatial probe test, the percent of swimming time in supposed platform quadrant （D quadrant）in both running groups were more than that of rats in respectively control groups（P〈0.05）, furthermore rats in 1 month running group had more frequency of crossing platform in D quadrant, where the plat- form situated,than that of rats in 1 month control group（P〈0. 05）and 13 month running group（P〈0.05 ）. There was no difference between the both 13 month groups. These findings suggest that treadmill running can enhance the ability of spatial learning and memory in young and adult rats, especially in young rats.