CAJ | 학술논문

为了进行大样本的老化与记忆的功能磁共振成像（fMRI）研究，研究者设计了言语工作记忆的方案，并且对一组健康青年人进行了施测。字母的呈现方式主要为两种条件：（i）保持，要求被试记住呈现的字母并且能够在4秒的间隔后保持；（ii）操控，被试需要将呈现的字母按字母表的顺序进行转换，并且记住新的顺序。不管是用全脑分析，还是用预先定义的感兴趣区域的分析方法，对fMRI数据的分析表明本方案诱发了可靠的额叶皮层的激活，且操控条件则引发了更为广泛的激活。背外侧和腹内侧前额叶的激活也表现出了不同特点，操控引发了更多的背外侧前额叶激活。一些皮下区域也得到了激活，特别是以前发现与工作记忆任务相关的一些区域。这说明该工作记忆研究方案适合探索额叶功能的与年龄相关的改变。
위료진행대양본적노화여기억적공능자공진성상（fMRI）연구，연구자설계료언어공작기억적방안，병차대일조건강청년인진행료시측。자모적정현방식주요위량충조건：（i）보지，요구피시기주정현적자모병차능구재4초적간격후보지；（ii）조공，피시수요장정현적자모안자모표적순서진행전환，병차기주신적순서。불관시용전뇌분석，환시용예선정의적감흥취구역적분석방법，대fMRI수거적분석표명본방안유발료가고적액협피층적격활，차조공조건칙인발료경위엄범적격활。배외측화복내측전액협적격활야표현출료불동특점，조공인발료경다적배외측전액협격활。일사피하구역야득도료격활，특별시이전발현여공작기억임무상관적일사구역。저설명해공작기억연구방안괄합탐색액협공능적여년령상관적개변。
A verbal working memory protocol was designed and evaluated on a group of healthy younger adults in preparation for a large-scale functional magnetic resonance （fMRI） study on aging and memory. Letters were presented in two critical conditions：（i） maintenance, in which letters were to be memorized and kept in mind over a four second interval, and （ii） manipulation, in which letters were shifted forward in alphabetical order, and the new order was kept in mind. Analyses of fMRI data showed that the protocol elicited reliable activation in the frontal cortex, with manipulation producing more extensive activation patterns, both in whole-brain analyses and in predefined regions of interest （ROIs）. There was also a distinction between dorsal and ventral lateral prefrontal regions, such that manipulation elicited more dorsolateral prefrontal activation. The protocol also elicited activation in various subcortical areas, previously associated with working-memory tasks. appropriate for investigating age-related changes in It was concluded that this working memory protocol is frontal-cortex functioning.