CAJ | 학술논문

创伤后应激障碍是个体经历严重应激后形成的一种焦虑障碍,对其治疗的关键是熄灭由创伤应激导致的条件性恐惧记忆。条件性恐惧的动物模型研究发现恐惧记忆一旦获得后就难以熄灭,容易复发,而这一点也是PTSD的关键临床症状表现之一。因此,如何更好更持久地熄灭恐惧记忆,是一个具有重要理论和临床意义的研究热点。本文围绕促进恐惧记忆的长久消退和破坏恐惧记忆的再巩固两方面的行为或药理干预及机制进行综述。针对本文所述的几种基础实验处理,临床上可以研究治疗创伤后应激障碍的相应疗法。
창상후응격장애시개체경력엄중응격후형성적일충초필장애,대기치료적관건시식멸유창상응격도치적조건성공구기억。조건성공구적동물모형연구발현공구기억일단획득후취난이식멸,용역복발,이저일점야시PTSD적관건림상증상표현지일。인차,여하경호경지구지식멸공구기억,시일개구유중요이론화림상의의적연구열점。본문위요촉진공구기억적장구소퇴화파배공구기억적재공고량방면적행위혹약리간예급궤제진행종술。침대본문소술적궤충기출실험처리,림상상가이연구치료창상후응격장애적상응요법。
Posttraumatic stress disorder （PTSD） is a kind of anxiety disorders developed from severe traumatic events.The key of treatment for this disorder is to extinguish conditioned fear memory.However,acquired fear memory is hard to be extinguished and extinguished fear memory is liable to recover in certain situations.Therefore,it is of great importance for PTSD theory and clinical practice to highlight the ways that persistently extinguish fear memory.In this review,we discuss two emotional regulation techniques that have been investigated as means to control fear：extinction and reconsolidation.Clinical PTSD treatment may be benefit from these pre-clinical methods which effectively extinguish fear memory.