CAJ | 학술논문

OPG／RANKL／RANK系统是成骨细胞和破骨细胞之间相互作用的信号通道，岂今为止所发现的最重要骨代谢调节机制。许多因素可以通过影响这个信号系统发挥对骨代谢的调节作用，机械力刺激就是一个非常重要的影响因素。在运动过程中肌肉不断的对骨骼施加机械力刺激，因此运动对骨骼的影响也可能是通过影响OPG／RANKL／RANK系统的表达而发挥调节作用。目前主流观点认为“内分泌激素分泌变化是运动影响骨健康的重要机制”，但这种观点值得重新思考，因为机械力可以直接刺激骨组织影响骨代谢，而运动通过改善体内激素分泌环境促进骨代谢平衡这只是一种间接调节方式，并且一般强度的健身运动根本不会明显影响激素的基础分泌，因此需要从更深层次阐明这一机制。随着0PG／RANKL／RANK骨代谢信号调节系统的发现，可能为这一领域的研究提供新的发展机遇，使我们能够在更微观的层面上探讨运动对骨骼影响的调节机制。
OPG／RANKL／RANK계통시성골세포화파골세포지간상호작용적신호통도，기금위지소발현적최중요골대사조절궤제。허다인소가이통과영향저개신호계통발휘대골대사적조절작용，궤계력자격취시일개비상중요적영향인소。재운동과정중기육불단적대골격시가궤계력자격，인차운동대골격적영향야가능시통과영향OPG／RANKL／RANK계통적표체이발휘조절작용。목전주류관점인위“내분비격소분비변화시운동영향골건강적중요궤제”，단저충관점치득중신사고，인위궤계력가이직접자격골조직영향골대사，이운동통과개선체내격소분비배경촉진골대사평형저지시일충간접조절방식，병차일반강도적건신운동근본불회명현영향격소적기출분비，인차수요종경심층차천명저일궤제。수착0PG／RANKL／RANK골대사신호조절계통적발현，가능위저일영역적연구제공신적발전궤우，사아문능구재경미관적층면상탐토운동대골격영향적조절궤제。
By far, OPG/RANKL/RANK system is the most important bone metabolism modulator, playing an essential role in the interaction between osteoblasts and osteoclasts. This system is affected by many hormones, cytokines and chemikinds, and mechanical strain is one of important regulating factor. Exercise exerts continuous mechanical strains on bone, therefore it can in- fluence on the OPG/RNAKL/RNAK system. It is well known that endocrinal hormones are the key mechanism in the influence of exercise on bone. However, this concept should be reconsidered, for the fact that mechanical strains can affect bone metabolism directly, and moderate physical activity may not change the secretion of hormone. With the discovery of OPG/RNAKL/ RNAK system, it will give out a glim on research in the regulatory mechanism of exercise affecting bone.