天津体育学院学报
天津體育學院學報
천진체육학원학보
Journal of Tianjin Institute of Physical Education
2010年
4期
282~286
,共null页
乌云格日勒 胡扬 衣龙彦 聂晶 王景玲 吉洪书
烏雲格日勒 鬍颺 衣龍彥 聶晶 王景玲 吉洪書
오운격일륵 호양 의룡언 섭정 왕경령 길홍서
HEPC基因多态性 HiHiLo训练 左心室结构 左心室功能
HEPC基因多態性 HiHiLo訓練 左心室結構 左心室功能
HEPC기인다태성 HiHiLo훈련 좌심실결구 좌심실공능
HEPC gene polymorphism; HIHILo training; left ventricular structure; left ventricular function
通过对HEPC基因SNP/A2032G与HiHiLo训练后左心室结构与功能指标变化的关联分析,从HEPC基因中筛选预测HiHiLo训练效果的分子标记。方法：对66名平原地区居住的北方汉族男子进行为期30天的HiHiLo训练,测定其训练前后安静状态和递增负荷运动下的左心室结构与功能指标。应用PCR-RFLP技术解析受试者SNP/A2032G多态性,采用关联方法分析SNP/A2032G与训练前后左心室结构功能指标变化的关联性。结果：（1）HiHiLo训练后,受试者ESD、EDD、PWD、IVSD、LVM和LVMI等6项心室结构指标均增长;心室功能指标中HR、CO、COI下降,而SV、SVI和EF增长。（2）HiHiLo训练后,AA型PWD和IVSD的增加量显著高于AG型和GG型,AA型100W/HR的下降量显著高于GG型,AA型Re/SV和Re/SVI的增加量显著高于AG型和GG型。结论：HEPC基因SNP/A2032G的AA型可以作为预测HiHiLo训练后心室结构和功能指标训练效果的分子标记。
通過對HEPC基因SNP/A2032G與HiHiLo訓練後左心室結構與功能指標變化的關聯分析,從HEPC基因中篩選預測HiHiLo訓練效果的分子標記。方法：對66名平原地區居住的北方漢族男子進行為期30天的HiHiLo訓練,測定其訓練前後安靜狀態和遞增負荷運動下的左心室結構與功能指標。應用PCR-RFLP技術解析受試者SNP/A2032G多態性,採用關聯方法分析SNP/A2032G與訓練前後左心室結構功能指標變化的關聯性。結果：（1）HiHiLo訓練後,受試者ESD、EDD、PWD、IVSD、LVM和LVMI等6項心室結構指標均增長;心室功能指標中HR、CO、COI下降,而SV、SVI和EF增長。（2）HiHiLo訓練後,AA型PWD和IVSD的增加量顯著高于AG型和GG型,AA型100W/HR的下降量顯著高于GG型,AA型Re/SV和Re/SVI的增加量顯著高于AG型和GG型。結論：HEPC基因SNP/A2032G的AA型可以作為預測HiHiLo訓練後心室結構和功能指標訓練效果的分子標記。
통과대HEPC기인SNP/A2032G여HiHiLo훈련후좌심실결구여공능지표변화적관련분석,종HEPC기인중사선예측HiHiLo훈련효과적분자표기。방법：대66명평원지구거주적북방한족남자진행위기30천적HiHiLo훈련,측정기훈련전후안정상태화체증부하운동하적좌심실결구여공능지표。응용PCR-RFLP기술해석수시자SNP/A2032G다태성,채용관련방법분석SNP/A2032G여훈련전후좌심실결구공능지표변화적관련성。결과：（1）HiHiLo훈련후,수시자ESD、EDD、PWD、IVSD、LVM화LVMI등6항심실결구지표균증장;심실공능지표중HR、CO、COI하강,이SV、SVI화EF증장。（2）HiHiLo훈련후,AA형PWD화IVSD적증가량현저고우AG형화GG형,AA형100W/HR적하강량현저고우GG형,AA형Re/SV화Re/SVI적증가량현저고우AG형화GG형。결론：HEPC기인SNP/A2032G적AA형가이작위예측HiHiLo훈련후심실결구화공능지표훈련효과적분자표기。
Objective： The association between SNP/A2032G in HEPC gene and the change of left ventricular structure and function after HiHiLo was analyzed and to provide as a genetic marker that can predict the efficiency of HiHiLo training.Methods： 66 male college-students from North of China were completed HiHiLo training for 30days and left ventricular structure/functional parameters in static and incremental exercise status for pre-post training was measured respectively.The SNP was differentiated by PCR-RFLP,then association between the change of left ventricular structure /function parameters and SNP/A2032G was analyzed by association studies with training response phenotypes.Results：（1） The ESD,EDD,PWD,IVSD,LVM and LVMI of subject were increased,and HR,CO and COI were decreased,but SV,SVI and EF were increased.（2） The increase of PWD and IVSD with AA were significantly higher than that AG and GG genotype,and an amount of decrease of 100W/HR with AA genotype was severity than GG genotype.Moreover,the increase of Re/SV and Re/SVI with AA genotype was significantly higher than AG and GG genotype.Conclusion： AA genotype of SNP/A2032G was maybe used as a genetic marker that can predict the efficiency with left ventricular structure/function after HiHiLo training.
