CAJ | 학술논문

为了观察运动对慢性应激抑郁模型大鼠行为学及体重的影响．通过慢性不可预知性应激（CUS）复制抑郁模型大鼠，以经典抗抑郁剂氟西汀（Flu）作为对照，观察中等强度跑台训练（MIR）、小强度跑台训练（LIR）对抑郁模型大鼠巧克力牛奶快感缺乏实验、开场实验、新奇抑制摄食实验的行为学表现和体重的影响。结果：（1）行为学研究：CUS明显使大鼠巧克力牛奶偏嗜度下降、自发活动减少、新奇环境中的摄食潜伏期延长；氟西汀可以明显对抗上述改变。慢性应激伴随进行运动具有与氟西汀一致的抗抑郁样行为作用。（2）体重变化：CUS显著抑制大鼠体重的增长，Flu、Flu＋MIR、Flu＋LIR均未能改善CUS大鼠体重增长的缓慢。MIR、LIR能够改善CUS大鼠体重增长缓慢的情况，每周体重与CUS组相比没有显著性差异。结果证明：抑郁模型大鼠出现快感缺乏、自发活动下降、摄食潜伏期延长的抑郁样行为表现和体重增长缓慢的躯体症状。运动对CUS大鼠具有与抗抑郁药氟西汀一致的抗抑郁行为学效应。
위료관찰운동대만성응격억욱모형대서행위학급체중적영향．통과만성불가예지성응격（CUS）복제억욱모형대서，이경전항억욱제불서정（Flu）작위대조，관찰중등강도포태훈련（MIR）、소강도포태훈련（LIR）대억욱모형대서교극력우내쾌감결핍실험、개장실험、신기억제섭식실험적행위학표현화체중적영향。결과：（1）행위학연구：CUS명현사대서교극력우내편기도하강、자발활동감소、신기배경중적섭식잠복기연장；불서정가이명현대항상술개변。만성응격반수진행운동구유여불서정일치적항억욱양행위작용。（2）체중변화：CUS현저억제대서체중적증장，Flu、Flu＋MIR、Flu＋LIR균미능개선CUS대서체중증장적완만。MIR、LIR능구개선CUS대서체중증장완만적정황，매주체중여CUS조상비몰유현저성차이。결과증명：억욱모형대서출현쾌감결핍、자발활동하강、섭식잠복기연장적억욱양행위표현화체중증장완만적구체증상。운동대CUS대서구유여항억욱약불서정일치적항억욱행위학효응。
In order to observe the effects of exercising on the ethological expressions and body weight of chronic stress induced depression model rats, the authors replicated depression model rats by means of chronic unpredictable stress （CUS）, used fluoxetine （Flu, a classical antidepressant） as a control, observed the effects of medium intensity treadmill running （MIR） and low intensity treadmill running （LIR） on the ethological expressions and body weight of depression model rats in chocolate milk anhedonia experiment, start experiment and novelty inhibition ingestion experiment, and revealed the following findings： 1） ethological study： CUS could significantly lower the degree of addiction of the rats to chocolate milk, reduce their spontaneous activity, and prolong their ingestion latent period in a novel environment; fluoxetine could significant counteract the said changes; with the continuance of exercising, chronic stress had fluoxetine consistent anti depression like behavior functions; 2） body weight change： CUS significantly inhibited the increase of body weight of the rats, Flu, Flu＋MIR and Flu＋LIR were all unable to improve the slow increase of body weight of CUS rats; M1R and LIR can improve the condition of slow increase of body weight of CUS rats; their weekly body weight had no significant difference as compared with the rats in the CUS group. The said findings proved the followings： depression model rats showed body symptoms of slow body weight increase and depression like ethological expressions such as anhedonia, spontaneous activity slowdown and ingestion latent period prolongation; exercising has fluoxetine consistent anti depression ethological effects on CUS rats.