CAJ | 학술논문

研制一种局部使用的用于治疗口腔溃疡的缓释西地碘口腔黏附片,并考察其对体外释放度和生物黏附性的影响.采用羧甲基纤维素钠（CMC-Na）和卡波姆（CP）为生物黏附材料,用直接粉末压片法制备的包括保护层和含药层的双层口腔黏附片.通过对不同处方黏附片的生物黏附力,体外黏附时间和溶胀速率进行测定,确定黏附剂的组成及用量,得到最佳的处方.含药层中黏附剂比例增加、乳糖比例减少及硬度的增大都会使释药速度减慢,硬度为4 kg左右时黏附力和释药比较好.处方中卡波姆比例用量、乳糖用量、黏附片硬度均对体外释药速度和黏附力有影响.
연제일충국부사용적용우치료구강궤양적완석서지전구강점부편,병고찰기대체외석방도화생물점부성적영향.채용최갑기섬유소납（CMC-Na）화잡파모（CP）위생물점부재료,용직접분말압편법제비적포괄보호층화함약층적쌍층구강점부편.통과대불동처방점부편적생물점부력,체외점부시간화용창속솔진행측정,학정점부제적조성급용량,득도최가적처방.함약층중점부제비례증가、유당비례감소급경도적증대도회사석약속도감만,경도위4 kg좌우시점부력화석약비교호.처방중잡파모비례용량、유당용량、점부편경도균대체외석약속도화점부력유영향.
This experiment is to design Cydiodine buccodhesive tablets with local use in the treatment of Oral ulcer,and to explore the factors that impact the release characteristics in vitro and bioadhesive capacity.Cydiodine buccodhesive tablets based on CP and CMC-Na at different ratios were prepared by direct compression of powders.The formulation of Cydiodine oral mucoadhesive tablets was optimized.The dissolution in adhesive time and swelling rate of cydiodine oral mucoadhesive tablets was evaluated by modified apparatus.And the ratio of the adhesive was ascertained,and then we can get the optimal recipe.The dissolution rate of Cydiodine from the mucoadhesive tablets was inversely proportioned to the amount of adhesive used as excipients and the hardness of the tablets and positively to the amount of lactose used.The adhesion and the dissolution rate were much better at the hardness index of 4 kiograms.It is concluded that the dissolution rate and adhesive capacity of the nisoldipine buccal adhesive tablets were significantly dependent on the proportions of CP/CMC-Na and lactose used as excipients and the hardness of the tablets.