天津体育学院学报
天津體育學院學報
천진체육학원학보
Journal of Tianjin Institute of Physical Education
2011年
1期
34~36
,共null页
纳米磁颗粒 碱性成纤维细胞生长因子 骨骼肌钝挫伤MHC-Ⅱb
納米磁顆粒 堿性成纖維細胞生長因子 骨骼肌鈍挫傷MHC-Ⅱb
납미자과립 감성성섬유세포생장인자 골격기둔좌상MHC-Ⅱb
magnetic nanoparticle; bFGF; skeletal muscle contusion MHC-Ⅱb
利用纳米磁性颗粒将bFGF定位于大鼠骨骼肌钝挫伤部位,考察该方法对大鼠急性骨骼肌钝挫伤恢复过程中收缩应力及MHC-Ⅱb表达影响。研究结果表明,bFGF对大鼠腓肠肌钝挫伤后第17、24天的收缩力有明显提高。损伤后第2~10天,bFGF包裹组与其余各组之间的MHC-ⅡbmRNA表达差异显著(P〈0.05)。因此,磁纳米化的bFGF能明显改善大鼠急性骨骼肌钝挫伤后的收缩应力衰减,显著促进损伤肌肉MHC-ⅡbmRNA的表达,改善损伤肌肉再生和结构修复。
利用納米磁性顆粒將bFGF定位于大鼠骨骼肌鈍挫傷部位,攷察該方法對大鼠急性骨骼肌鈍挫傷恢複過程中收縮應力及MHC-Ⅱb錶達影響。研究結果錶明,bFGF對大鼠腓腸肌鈍挫傷後第17、24天的收縮力有明顯提高。損傷後第2~10天,bFGF包裹組與其餘各組之間的MHC-ⅡbmRNA錶達差異顯著(P〈0.05)。因此,磁納米化的bFGF能明顯改善大鼠急性骨骼肌鈍挫傷後的收縮應力衰減,顯著促進損傷肌肉MHC-ⅡbmRNA的錶達,改善損傷肌肉再生和結構脩複。
이용납미자성과립장bFGF정위우대서골격기둔좌상부위,고찰해방법대대서급성골격기둔좌상회복과정중수축응력급MHC-Ⅱb표체영향。연구결과표명,bFGF대대서비장기둔좌상후제17、24천적수축력유명현제고。손상후제2~10천,bFGF포과조여기여각조지간적MHC-ⅡbmRNA표체차이현저(P〈0.05)。인차,자납미화적bFGF능명현개선대서급성골격기둔좌상후적수축응력쇠감,현저촉진손상기육MHC-ⅡbmRNA적표체,개선손상기육재생화결구수복。
To study the effects of basic fibroblast growth factor(bFGF)-coated magnetic nanoparticles on the recovery and regeneration in rat skeletal muscles after acute contusion.bFGF could significantly increased the muscle contractive strength at day 17 and day 24 in gastrocnemius after contusion.From day 2 after contusion,bFGF could restore the muscle relaxation back close to the normal level.The bFGF-coated group was significantly different from other four groups in the expression of at day 2-10 after contusion(P0.05).The bFGF-coated group could significantly enhance the contractive strength,promote the expression of MHC-Ⅱb mRNA,and improve the regeneration and structure healing of injured muscles in rat acute skeletal muscle contusion.