CAJ | 학술논문

目的：探讨振动刺激对大鼠废用性比目鱼肌萎缩的影响作用。方法：将40只雌性SD大鼠随机分为对照组（A）、振动组（B）、悬吊组（C）、自然恢复组（D）等4组。悬吊14 d后,取C组大鼠比目鱼肌称其湿重,振动刺激训练4周后取其余3组大鼠比目鱼肌称其湿重,比较4组湿重体重比。并对大鼠比目鱼肌Ⅰ、Ⅱ型肌纤维比例、平均横截面积（CSA）进行定量分析。结果：与A组相比,C组湿重体重比明显减小,Ⅰ型纤维比例减少而Ⅱ型纤维比例增加（P〈0.05）。BD组湿重体重比、Ⅰ型平均横截面积高于C组,B组Ⅰ型肌纤维的比例高于C组（P〈0.05）。结论振动刺激能有效地对抗悬吊引起的大鼠比目鱼肌废用性萎缩。
목적：탐토진동자격대대서폐용성비목어기위축적영향작용。방법：장40지자성SD대서수궤분위대조조（A）、진동조（B）、현조조（C）、자연회복조（D）등4조。현조14 d후,취C조대서비목어기칭기습중,진동자격훈련4주후취기여3조대서비목어기칭기습중,비교4조습중체중비。병대대서비목어기Ⅰ、Ⅱ형기섬유비례、평균횡절면적（CSA）진행정량분석。결과：여A조상비,C조습중체중비명현감소,Ⅰ형섬유비례감소이Ⅱ형섬유비례증가（P〈0.05）。BD조습중체중비、Ⅰ형평균횡절면적고우C조,B조Ⅰ형기섬유적비례고우C조（P〈0.05）。결론진동자격능유효지대항현조인기적대서비목어기폐용성위축。
Objective： to study counteracting effects of vibration stimulate skeletal muscle disuse atrophy（SMDA） in rats soleus muscles.Methods： 40 Female SD rats were assigned randomly to one of the four groups：simultaneous control（A）,suspension plus vibration stimulate（B）,suspension（C）,and suspension control（D）.Soleus muscles were examined 14 days later.Sections were treated with mATPase stain.The cross-sectional areas（CSA）of fibers,the relative proportion of types I and II were measured using Leica image analysis system.Results： Compared with those of group A,the wet weight/body of soleus in group C were significantly reduced,while the relative proportion of type I fibers was reduced and type II fibers increased.Compared with group C,the wet weight/body of soleus recovered completely in group BD,and the CSA of type I fibers recovered partly in group B.The relative proportion of type I fibers recovered in group B（P0.05）.Conclusion： The present study showed that VS is effective in counteracting the muscular atrophy of disuse induced by simulated weightlessness.