CAJ | 학술논문

药物成瘾是以强迫性觅药和用药行为为核心特征的慢性脑疾病。从初始用药到强迫性用药是成瘾者的觅药行为从目标导向性向习惯化发展的过程。强迫性觅药和用药行为是依赖于背外侧纹状体的习惯化行为,同时前额叶皮层-背内侧纹状体通路对行为的控制减弱,导致感觉运动皮层-背外侧纹状体通路对行为的控制持续占主导地位,是成瘾行为具有强迫性特征的重要神经基础。本项目围绕这一重要问题展开研究,在建立具有成瘾特征的动物模型的基础上,采用行为学、行为药理学和组织形态学等方法揭示皮层-纹状体通路在强迫性觅药和用药行为中的作用。研究结果有望为进一步寻找该神经网络参与成瘾行为的分子机制提供重要线索。
약물성은시이강박성멱약화용약행위위핵심특정적만성뇌질병。종초시용약도강박성용약시성은자적멱약행위종목표도향성향습관화발전적과정。강박성멱약화용약행위시의뢰우배외측문상체적습관화행위,동시전액협피층-배내측문상체통로대행위적공제감약,도치감각운동피층-배외측문상체통로대행위적공제지속점주도지위,시성은행위구유강박성특정적중요신경기출。본항목위요저일중요문제전개연구,재건립구유성은특정적동물모형적기출상,채용행위학、행위약이학화조직형태학등방법게시피층-문상체통로재강박성멱약화용약행위중적작용。연구결과유망위진일보심조해신경망락삼여성은행위적분자궤제제공중요선색。
Drug addiction is a chronic brain disease characterized by compulsive drug seeking and taking behaviors. From initially go-directed drug use to compulsive drug taking, the drug-seeking behavior in addicts becomes more and more habitual. Compulsive drug seeking and taking behaviors are habitual behaviors depending on dorsolateral striatum, and the impaired function of the prefrontal cortex-dorsomedial striatum pathway, which leads to persistent control of behavior by sensorimotor cortex-dorsolateral striatum pathway, is an important neural mechanism underlying compulsive addicted behaviors. The study will establish the animal model of drug addiction and adopt behavioral, behavioral pharmacological and morphological techniques to discover the role of the cortex-striatum pathway in compulsive drug seeking and taking behaviors. The results may shed light on the possible molecular mechanisms involved in drug addiction.