北京体育大学学报
北京體育大學學報
북경체육대학학보
Journal of Beijing University of Physical Education
2011年
6期
63~67
,共null页
有氧运动 茶多酚 高脂膳食 糖脂代谢 炎症因子
有氧運動 茶多酚 高脂膳食 糖脂代謝 炎癥因子
유양운동 다다분 고지선식 당지대사 염증인자
Aerobic exercise; polyphenols; high-fat diet; glucose and lipid metabolism; inflammatory factors
目的：研究有氧运动和补充茶多酚对高脂膳食大鼠糖脂代谢及炎症因子TNF-α和IL-6的影响,并探讨炎症因子TNF-α和IL-6在营养性肥胖所致的糖脂代谢异常及胰岛素抵抗中的作用。方法：3周龄SD雄性大鼠50只,随机分为普通膳食对照组（C组）、高脂膳食对照组（H组）、有氧运动组（HE组）、茶多酚组（HT组）和综合干预组（HET组）。C组以普通饲料饲养,其余各组均以高脂饲料饲养;HE组和HET组大鼠进行为期8周的无负重游泳训练;HT组和HET组大鼠每周6 D以1 g/kg体重剂量的茶多酚灌胃。8周后测试大鼠糖脂代谢相关指标及炎症因子TNF-α和IL-6。结果：与C组相比,H组大鼠体重显著增加,血清GLU、TC、TG和FINS显著增加,血清和脂肪组织中TNF-α和IL-6显著增加;与H组相比,HE组、HT组和HET组大鼠上述指标有所降低,而以HET组降低幅度最为显著。结论：有氧运动和补充茶多酚均可改善高脂膳食引起的糖脂代谢异常和胰岛素抵抗,且以联合应用有氧运动和补充茶多酚的综合干预措施效果最为显著。有氧运动和补充茶多酚对高脂膳食所致糖脂代谢异常和胰岛素抵抗的改善作用与其抑制脂肪组织炎症因子TNF-α和IL-6的表达和分泌密切相关。
目的：研究有氧運動和補充茶多酚對高脂膳食大鼠糖脂代謝及炎癥因子TNF-α和IL-6的影響,併探討炎癥因子TNF-α和IL-6在營養性肥胖所緻的糖脂代謝異常及胰島素牴抗中的作用。方法：3週齡SD雄性大鼠50隻,隨機分為普通膳食對照組（C組）、高脂膳食對照組（H組）、有氧運動組（HE組）、茶多酚組（HT組）和綜閤榦預組（HET組）。C組以普通飼料飼養,其餘各組均以高脂飼料飼養;HE組和HET組大鼠進行為期8週的無負重遊泳訓練;HT組和HET組大鼠每週6 D以1 g/kg體重劑量的茶多酚灌胃。8週後測試大鼠糖脂代謝相關指標及炎癥因子TNF-α和IL-6。結果：與C組相比,H組大鼠體重顯著增加,血清GLU、TC、TG和FINS顯著增加,血清和脂肪組織中TNF-α和IL-6顯著增加;與H組相比,HE組、HT組和HET組大鼠上述指標有所降低,而以HET組降低幅度最為顯著。結論：有氧運動和補充茶多酚均可改善高脂膳食引起的糖脂代謝異常和胰島素牴抗,且以聯閤應用有氧運動和補充茶多酚的綜閤榦預措施效果最為顯著。有氧運動和補充茶多酚對高脂膳食所緻糖脂代謝異常和胰島素牴抗的改善作用與其抑製脂肪組織炎癥因子TNF-α和IL-6的錶達和分泌密切相關。
목적：연구유양운동화보충다다분대고지선식대서당지대사급염증인자TNF-α화IL-6적영향,병탐토염증인자TNF-α화IL-6재영양성비반소치적당지대사이상급이도소저항중적작용。방법：3주령SD웅성대서50지,수궤분위보통선식대조조（C조）、고지선식대조조（H조）、유양운동조（HE조）、다다분조（HT조）화종합간예조（HET조）。C조이보통사료사양,기여각조균이고지사료사양;HE조화HET조대서진행위기8주적무부중유영훈련;HT조화HET조대서매주6 D이1 g/kg체중제량적다다분관위。8주후측시대서당지대사상관지표급염증인자TNF-α화IL-6。결과：여C조상비,H조대서체중현저증가,혈청GLU、TC、TG화FINS현저증가,혈청화지방조직중TNF-α화IL-6현저증가;여H조상비,HE조、HT조화HET조대서상술지표유소강저,이이HET조강저폭도최위현저。결론：유양운동화보충다다분균가개선고지선식인기적당지대사이상화이도소저항,차이연합응용유양운동화보충다다분적종합간예조시효과최위현저。유양운동화보충다다분대고지선식소치당지대사이상화이도소저항적개선작용여기억제지방조직염증인자TNF-α화IL-6적표체화분비밀절상관。
Objective： Study of the effect of aerobic exercise and supplement of tea polyphenols on glucose and lipid metabolism and lipid inflammatory cytokines TNF-α and IL-6 in high-fat diet rats,and analyze the role of inflammatory cytokines TNF-α and IL-6 in the nutrient-induced obesity and disorders of glucose and lipid metabolism and insulin resistance.Method： There were fifty 3-week old SD male rats,they were randomly divided into normal diet control group（C group）,high fat diet control group（H group）,aerobic exercise group（HE group）,tea polyphenols group（HT group） and comprehensive intervention group（HET group）.C group were fed normal diet,other groups were fed high fat diet.Rats of HE group and HET group were trained to swim without additional load which last 8 weeks,Rats of HT group and HET group were fed with tea polyphenols 1 g/kg body weight per day,6 days per week.After 8 weeks,glucose and lipid metabolism associated index and inflammatory factors TNF-α and IL-6 were test.Result： Compared with the C group,the body weight,serum GLU,TC,TG,FINS were significantly increased,and the TNF-α and IL-6 were significantly increased in serum and adipose tissue.Compared with the H group,the index of HE group,HT group and HET group rats were decreased,and the reduction of HET group was most significant.Conclusion： Aerobic exercise and supplements of tea polyphenols can ease the disorders of glucose and lipid metabolism and insulin resistance caused by high fat diet,and the combination of aerobic exercise and supplements of tea is the most significant.The effect of aerobic exercise and supplements of tea polyphenols on glucose and lipid metabolism and insulin resistance are closely related with their inhibition of inflammatory cytokines TNF-α and IL-6 expression and secretion.
