CAJ | 학술논문

安慰剂处理从最初作为研究某种真实治疗效应的控制条件，已演变为研究者直接关注的研究目标，其实验范式也发生了相应变化。双盲随机设计关注真实的治疗是否优于安慰剂处理：欺骗设计直接比较安慰剂处理效应和自然历史效应的差异，关注安慰剂效应本身；公开隐藏设计通过计算公开治疗效应和隐藏治疗效应之差来估计安慰剂效应的大小；平衡范式可同时观察安慰剂效应和真实治疗效应；强化范式通过条件性强化获得加强的安慰剂效应，是研究其作用机制的优化方案；本课题组建立的迁移强化范式，研究安慰剂效应从痛觉到情绪的迁移，是强化范式的重要补充。
안위제처리종최초작위연구모충진실치료효응적공제조건，이연변위연구자직접관주적연구목표，기실험범식야발생료상응변화。쌍맹수궤설계관주진실적치료시부우우안위제처리：기편설계직접비교안위제처리효응화자연역사효응적차이，관주안위제효응본신；공개은장설계통과계산공개치료효응화은장치료효응지차래고계안위제효응적대소；평형범식가동시관찰안위제효응화진실치료효응；강화범식통과조건성강화획득가강적안위제효응，시연구기작용궤제적우화방안；본과제조건립적천이강화범식，연구안위제효응종통각도정서적천이，시강화범식적중요보충。
Placebo treatment initially was a controlled condition in studying certain active therapeutic effect, but now it has been the study object that the investigators who are interested in. And the experimental paradigm also has kept changing accordingly. Randomized and double-blind design concerns about if the active therapy is more effective than placebo treatment; Deceptive design investigates placebo effect itself by directly compared the placebo treatment and natural history condition; Open-hidden paradigm estimates the size of placebo effect by subtracting hidden effect from open effect; Balanced paradigm can observe placebo effect and therapeutic effect simutaneously; Reinforcement paradigm can produce strong placebo effect with conditioned reinforcement and is an optimized paradigm for studying the mechanism of placebo effect; Transferable paradigm built by our team, can observe the transferable effect from pain domain to emotion domain, is a complement to reinforcement paradigm.