心理学报
心理學報
심이학보
Acta Psychologica Sinica
2011年
8期
917~928
,共null页
于萍 袁水霞 李霞 千罩Jl 徐晖 尹文娟 顾凯 左洋凡 卢钦钦 代淑芬 郭春彦
于萍 袁水霞 李霞 韆罩Jl 徐暉 尹文娟 顧凱 左洋凡 盧欽欽 代淑芬 郭春彥
우평 원수하 리하 천조Jl 서휘 윤문연 고개 좌양범 로흠흠 대숙분 곽춘언
空间工作记忆 海马 位置细胞 位置野 多通道记录
空間工作記憶 海馬 位置細胞 位置野 多通道記錄
공간공작기억 해마 위치세포 위치야 다통도기록
spatial working memory; hippocampus; place cell; place field; muti-channel recording
观察空间工作记忆过程中海马CA1区神经元群的放电特征。应用多通道神经元集群放电记录技术,同步观察和记录清醒大鼠在执行延迟选择任务时的行为轨迹以及海马CA1区神经元的放电活动。发现:海马CA1区位置细胞的位置野是在学习过程中逐渐形成并可消退;部分位置细胞的放电对未来目标定向性行为具有预测作用;在空间工作记忆过程中,神经元放电之间的相关性加强,神经元之间以及神经元与局部场电位之间存在相位编码方式。结果提示海马CA1区神经元参与对空间信息的初级编码和加工,并为未来行为决策提供有效信息,而且海马对信息的加工是通过局部神经网络进行,时间编码可能是海马信息加工的重要方式之一。
觀察空間工作記憶過程中海馬CA1區神經元群的放電特徵。應用多通道神經元集群放電記錄技術,同步觀察和記錄清醒大鼠在執行延遲選擇任務時的行為軌跡以及海馬CA1區神經元的放電活動。髮現:海馬CA1區位置細胞的位置野是在學習過程中逐漸形成併可消退;部分位置細胞的放電對未來目標定嚮性行為具有預測作用;在空間工作記憶過程中,神經元放電之間的相關性加彊,神經元之間以及神經元與跼部場電位之間存在相位編碼方式。結果提示海馬CA1區神經元參與對空間信息的初級編碼和加工,併為未來行為決策提供有效信息,而且海馬對信息的加工是通過跼部神經網絡進行,時間編碼可能是海馬信息加工的重要方式之一。
관찰공간공작기억과정중해마CA1구신경원군적방전특정。응용다통도신경원집군방전기록기술,동보관찰화기록청성대서재집행연지선택임무시적행위궤적이급해마CA1구신경원적방전활동。발현:해마CA1구위치세포적위치야시재학습과정중축점형성병가소퇴;부분위치세포적방전대미래목표정향성행위구유예측작용;재공간공작기억과정중,신경원방전지간적상관성가강,신경원지간이급신경원여국부장전위지간존재상위편마방식。결과제시해마CA1구신경원삼여대공간신식적초급편마화가공,병위미래행위결책제공유효신식,이차해마대신식적가공시통과국부신경망락진행,시간편마가능시해마신식가공적중요방식지일。
Hippocampus plays a vital role in the formation of spatial working memory. The brain encodes spatial information by generating spatial cognitive map in hippocampus. The mechanism with which hippocampus encodes, integrates, and extracts information remains unclear. According to Hebb's cell assembly hypothesis, spatial information is distributed in neural network. In this study, the dynamic processing of neuronal information in hippocampus CA1 neurons was observed in behaving adult rats and the neuronal mechanisms of spatial working memory were analyzed. A 16-channel (2x8) multi-electrode array was surgically imbedded into hippocampus CA1 area under general anesthetization. After the animals recovered from the surgery, they were trained in T-maze for delay-alternation task. 13 training trials (inter-trials interval 20 sec) were performed each day for about 7-14days. The multi-electrode array was cable-connected to a multi-channel acquisition system for simultaneous recording and displaying of neuronal units discharges and local field potentials. While the neuronal signals and animal spatial positions were recorded, the event marker was inputted in synchrony. Relationships between the events and neuronal unit discharges or local field potentials were analyzed during spatial memory formation. It was found that hippocampus CA1 neurons exhibited discharges correlating to door-opening and turning. Based on the correlating events, CA1 neurons can be classified into door-opening neurons, turning neurons, and double-place field neurons. When the animals were in the stem of the T-maze, hippocampus neurons showed context-dependent differential discharging. Some neurons showed discharges that predicted goal-directed behavior. The place fields of place neurons were gradually formed during learning and memory, but they were not stable until the formation of memory. The correlations between neurons also became stronger during memory formation. The same or different theta oscillation (4-12Hz) was observed between neuronal discharges or between neuronal discharge and local field potential. Besides, the theta oscillation exhibited event-correlation: it appeared before door-opening or turning. The results suggest that neurons in CA1 area of hippocampus are involved in the primary processing of spatial information to guide the prospective search behavior. In the formation of spatial memory, hippocampus neuronal assembly process information not only through spatial encoding, but also through temporal encoding.