广州体育学院学报
廣州體育學院學報
엄주체육학원학보
Journal of Guangzhou Physical Education Institute
2011年
5期
80~83
,共null页
于洋 杨贤罡 王卓涛 周君一
于洋 楊賢罡 王卓濤 週君一
우양 양현강 왕탁도 주군일
急性力竭运动 肾组织 TXA2/PG12代谢平衡 自由基代谢
急性力竭運動 腎組織 TXA2/PG12代謝平衡 自由基代謝
급성력갈운동 신조직 TXA2/PG12대사평형 자유기대사
Acute Exhaustive Exercise; Renal Tissue; TXA2/PGI2 Metabolism Balance; Free Radical Metabolism
目的:探讨急性力竭运动及恢复期过程中肾脏TXA2/PGI2代谢平衡调节的生物学效应及自由基代谢的介导作用。方法:SD大鼠随机分为安静对照组、运动后即刻组、运动后1h组、3h组和24h组,各运动组采用递增负荷跑台运动至力竭方案,测定肾组织中TXB2、6-keto—F1α和MDA含量和SOD活性。结果:运动后即刻肾脏TXB2含量和TXB2/6-keto—F1α比值均显著下降,恢复期TXB2含量和TXB2/6-keto—F1α比值均显著低于安静水平。运动及恢复期肾组织SOD活性、MDA含量与TXB2、6-keto—F1α含量均呈显著负相关。结论:力竭运动及恢复期肾脏TXA2/PG12平衡均下调,运动中有利于维持肾脏局部基本的血液供应,可能与运动性肾脏缺血激发局部代偿机制有关,恢复期则促进肾脏血液再灌注和恢复血供。肾脏抗自由基能力提高可能主要通过抑制肾脏TXA2合成下调TXA2/PGI2平衡。
目的:探討急性力竭運動及恢複期過程中腎髒TXA2/PGI2代謝平衡調節的生物學效應及自由基代謝的介導作用。方法:SD大鼠隨機分為安靜對照組、運動後即刻組、運動後1h組、3h組和24h組,各運動組採用遞增負荷跑檯運動至力竭方案,測定腎組織中TXB2、6-keto—F1α和MDA含量和SOD活性。結果:運動後即刻腎髒TXB2含量和TXB2/6-keto—F1α比值均顯著下降,恢複期TXB2含量和TXB2/6-keto—F1α比值均顯著低于安靜水平。運動及恢複期腎組織SOD活性、MDA含量與TXB2、6-keto—F1α含量均呈顯著負相關。結論:力竭運動及恢複期腎髒TXA2/PG12平衡均下調,運動中有利于維持腎髒跼部基本的血液供應,可能與運動性腎髒缺血激髮跼部代償機製有關,恢複期則促進腎髒血液再灌註和恢複血供。腎髒抗自由基能力提高可能主要通過抑製腎髒TXA2閤成下調TXA2/PGI2平衡。
목적:탐토급성력갈운동급회복기과정중신장TXA2/PGI2대사평형조절적생물학효응급자유기대사적개도작용。방법:SD대서수궤분위안정대조조、운동후즉각조、운동후1h조、3h조화24h조,각운동조채용체증부하포태운동지력갈방안,측정신조직중TXB2、6-keto—F1α화MDA함량화SOD활성。결과:운동후즉각신장TXB2함량화TXB2/6-keto—F1α비치균현저하강,회복기TXB2함량화TXB2/6-keto—F1α비치균현저저우안정수평。운동급회복기신조직SOD활성、MDA함량여TXB2、6-keto—F1α함량균정현저부상관。결론:력갈운동급회복기신장TXA2/PG12평형균하조,운동중유리우유지신장국부기본적혈액공응,가능여운동성신장결혈격발국부대상궤제유관,회복기칙촉진신장혈액재관주화회복혈공。신장항자유기능력제고가능주요통과억제신장TXA2합성하조TXA2/PGI2평형。
Objective: To explore the biological effect of TXA2/PGI2 metabolism balance and mediate role of free radicals metabolism during acute exhaustive exercise and recovery period. Method: Forty - two SD rats were divided into five groups at random, control group (C, n = 8 ), immediately after exercise group( E0, n = 9), 1 h, 3h and 24h after exercise groups( E1, n = 9 ; E3, n = 8 ; E24, n = 8 ). Rats in exercise groups was given an process of incremental loading treadmill running to exhaustive. TXB2, 6 -keto- Flu and MDA content, SOD activity in renal tissue were determinated. Result: TXB2 content and TXB2/6 -keto - F1α ratio in renal tissue significantly decreased immediately after running, while 6 - keto - F1α decreased without statistically significant difference. During recovery period, TXB2 content and TXB2/6 -keto- F1α ratio were still significantly lower than baseline, whereas had no difference with the levels of immediately after running. There was significant negative correlation between TXB2, 6 -keto- F1α content and SOD activity, MDA contents found. Conclusion: The down - regulated of TXA2/PGI2 metabolism was beneficial to renal fundamental blood supply during exercise which may be related to local compensatory mechanism, and also beneficial to renal blood reperfusion and blood supply recovery during recovery period. Increased anti - free radical ability down - regulated TXA2/PGI2 metabolism balance, and this effects may mainly be related to inhibit TXA2 synthesis.